ArticleJournal of the American Geriatrics Society2024
Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality.
Article in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Healthy diet and slower biological aging as protective factors against microvascular complications in type 2 diabetes.GeroScience · 2026Article
- A Lifestyle Behavior Score Predicting Cardiovascular and Other Causes of Death in a Cohort of Middle-Aged Men Followed up Until Extinction.Journal of cardiovascular development and disease · 2026Article
- Associations Between Welding-Related Metals and Atherosclerotic Cardiovascular Disease Risk in Male Welders: The Mediating Role of Accelerated Biological Aging.Cardiovascular toxicology · 2026Article
- Phenotypic age acceleration as a novel predictor of benign prostatic hyperplasia: a prospective cohort study.GeroScience · 2026Article
- The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank.The journal of nutrition, health & aging · 2026Article
- Association of accelerated phenotypic aging, lifestyle and genetic risk with progression of cardiometabolic multimorbidity: a multi-state model analysis.GeroScience · 2026Article
- Phenotypic age acceleration: a novel biomarker associated with increased risk of metabolic dysfunction-associated fatty liver disease.Nutrition & metabolism · 2026Article
- Accelerated biological aging, genetic susceptibility, and lifestyle in relation to abdominal aortic aneurysm: A prospective study.The journal of nutrition, health & aging · 2026Article
- Review of Therapeutic Potential of Coenzyme Q10 in Ophthalmology: Focus on Age-Related Macular Degeneration, Glaucoma, and Retinitis Pigmentosa.Antioxidants (Basel, Switzerland) · 2026Review
- Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study.BMC cardiovascular disorders · 2026Article
- Association between accelerated biological aging and major adverse cardiovascular events in patients with stable coronary artery disease.The journal of nutrition, health & aging · 2026Article
- Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study.npj aging · 2026Article
- Aging and increased cancer risk: exploring the potential of LE8 score to mitigate risk.npj aging · 2026Article
- Cultural Engagement Is Related to Decelerated Physiological Age: Doubly Robust Estimations in a National Cohort Study.Annals of the New York Academy of Sciences · 2026Article
- Accelerated aging mediates the association between fecal incontinence and mortality: Evidence from the National Health and Nutrition Examination Survey.The Journal of international medical research · 2026Article
- Association of total fish-shellfish consumption with biological aging: a cross-sectional analysis of NHANES 1999-2020 with mediation by inflammatory and antioxidant biomarkers.Irish journal of medical science · 2026Article
- Social connections are differentially related to subjective age and physiological age acceleration amongst older adults.Nature communications · 2026Article
- Biological aging, a mediator between smoking and chronic obstructive pulmonary disease: evidence from a hospital-based cohort study in China.BMC pulmonary medicine · 2026Article
- Associations of biological ageing and genetic risk with incident abdominal aortic aneurysm.Communications medicine · 2026Article
- Accelerated Biological Aging, Genetic Predisposition, and Incident Valvular Heart Disease.JACC. Asia · 2026Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundWith two well-validated aging measures capturing mortality and morbidity risk, this study examined whether and to what extent aging mediates the associations of unhealthy lifestyles with adverse health outcomes.
methodsData were from 405,944 adults (40-69 years) from UK Biobank (UKB) and 9972 adults (20-84 years) from the US National Health and Nutrition Examination Survey (NHANES). An unhealthy lifestyles score (range: 0-5) was constructed based on five factors (smoking, drinking, physical inactivity, unhealthy body mass index, and unhealthy diet). Two aging measures, Phenotypic Age Acceleration (PhenoAgeAccel) and Biological Age Acceleration (BioAgeAccel) were calculated using nine and seven blood biomarkers, respectively, with a higher value indicating the acceleration of aging. The outcomes included incident cardiovascular disease (CVD), incident cancer, and all-cause mortality in UKB; CVD mortality, cancer mortality, and all-cause mortality in NHANES. A general linear regression model, Cox proportional hazards model, and formal mediation analysis were performed.
resultsThe unhealthy lifestyles score was positively associated with PhenoAgeAccel (UKB: β = 0.741; NHANES: β = 0.874, all p < 0.001). We further confirmed the respective associations of PhenoAgeAccel and unhealthy lifestyles with the outcomes in UKB and NHANES. The mediation proportion of PhenoAgeAccel in associations of unhealthy lifestyles with incident CVD, incident cancer, and all-cause mortality were 20.0%, 17.8%, and 26.6% (all p < 0.001) in UKB, respectively. Similar results were found in NHANES. The findings were robust when using another aging measure-BioAgeAccel.
conclusionsAccelerated aging partially mediated the associations of lifestyles with CVD, cancer, and mortality in UK and US populations. The findings reveal a novel pathway and the potential of geroprotective programs in mitigating health inequality in late life beyond lifestyle interventions.
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