Evidence map›Paper›PMID 37790482›Full record

ArticlebioRxiv : the preprint server for biology2023

Cardiomyocyte-specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy.

Jiangbin Wu, Jared Hollinger, Emily Bonanno, Feng Jiang, Peng Yao

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiangbin WuAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642 USA.
Jared HollingerAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642 USA.
Emily BonannoUndergraduate Program in Biology and Medicine, Department of Biological Sciences: Biochemistry, University of Rochester, Rochester, New York 14620 USA.
Feng JiangAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642 USA.
Peng YaoAab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York 14642 USA.
University of Rochester · US

Funding

uORF-mediated Translational Control of Cardiac Transcription Factor ExpressionR01HL164584 · NHLBI · UNIVERSITY OF ROCHESTER · PI Peng Yao · 2023 to 2026
$2.0M
Deciphering the role of FAM210A in cardiac physiopathologyR01HL169432 · NHLBI · UNIVERSITY OF ROCHESTER · PI Peng Yao · 2023 to 2026
$1.9M
Role of miR-574-Fam210a axis in cardiac hypertrophy and remodelingR01HL132899 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAO, PENG · 2018 to 2021
$1.5M
Translational Control of Cardiac FibrosisR01HL147954 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAO, PENG · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL132899NHLBI NIH HHS R01 HL147954NHLBI NIH HHS R01 HL164584NHLBI NIH HHS R01 HL169432
6 · The paper itself

Abstract

Glutamyl-prolyl-tRNA synthetase (EPRS1), an aminoacyl-tRNA synthetase (ARS) ligating glutamic acid and proline to their corresponding tRNAs, plays an essential role in decoding proline codons during translation elongation. The physiological function of EPRS1 in cardiomyocytes (CMs) and the potential effects of CM-specific loss of EPRS1 remain unknown. Here, we found that heterozygous

Indexed as

cardiomyocytecardiomyopathyEPRS1heart failuretranslational control

Identifiers

PMID37790482
PMCPMC10542137
OpenAlexW4386946849

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.