Evidence map›Paper›PMID 37790821›Full record

ReviewJournal of hand surgery global online2023

Let's Focus on the Fibrosis in Dupuytren Disease: Cell Communication Network Factor 2 as a Novel Target.

Alex G Lambi, Nathan T Morrell, Steven N Popoff, Prosper Benhaim, Mary F Barbe

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hand surgery global online, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alex G LambiDepartment of Orthopedics and Rehabilitation, University of New Mexico School of Medicine, Albuquerque, NM.
Nathan T MorrellDepartment of Orthopedics and Rehabilitation, University of New Mexico School of Medicine, Albuquerque, NM.
Steven N PopoffDepartment of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Prosper BenhaimDepartment of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA.
Mary F BarbeDepartment of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Temple University · USUniversity of New Mexico · USUniversity of California, Los Angeles · US

Funding

Biomarkers of Tissue Tolerance and Behavior in a Rat ModelR01AR056019 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI BARBE, MARY F · 2009 to 2025
$7.3M
NIAMS NIH HHS R01 AR056019
6 · The paper itself

Abstract

Dupuytren disease is a progressive, benign fibroproliferative disorder of the hands that can lead to debilitating hand contractures. Once symptomatic, treatment involves either surgical intervention, specifically fasciectomy or percutaneous needle aponeurotomy, or enzymatic degradation with clostridial collagenase. Currently, collagenase is the only pharmacotherapy that has been approved for the treatment of Dupuytren contracture. There is a need for a pharmacotherapeutic that can be administered to limit disease progression and prevent recurrence after treatment. Targeting the underlying fibrotic pathophysiology is critical. We propose a novel target to be considered in Dupuytren disease-cell communication network factor 2/connective tissue growth factor-an established mediator of musculoskeletal tissue fibrosis.

Indexed as

CCN2 proteinConnective tissue growth factorDupuytren contractureFibrosisTGF-beta

Identifiers

PMID37790821
PMCPMC10543811
OpenAlexW4385455230

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.