Evidence map›Paper›PMID 37791766›Full record

ArticleAutophagy2024

Invariant BECN1 CXXC motifs bind Zn

Shreya Mukhopadhyay, Subeksha Subedi, Jesse B Hopkins, Angel Ugrinov, Srinivas Chakravarthy, Christopher L Colbert, Sangita C Sinha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The human autophagy-initiating complexes ULK1C and PI3KC3-C1.The Journal of biological chemistry · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shreya MukhopadhyayDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA.
Subeksha SubediDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA.
Jesse B HopkinsThe Biophysics Collaborative Access Team, Departments of Biology and Physics, Illinois Institute of Technology, Chicago, IL, USA.
Angel UgrinovDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA.
Srinivas ChakravarthyThe Biophysics Collaborative Access Team, Departments of Biology and Physics, Illinois Institute of Technology, Chicago, IL, USA.
Christopher L ColbertDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA.
Sangita C SinhaDepartment of Chemistry and Biochemistry, North Dakota State University, Fargo, ND, USA.ORCID 0000-0003-0953-4263

Funding

The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
Pilot Projects: Core DP30GM103332 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SIBI, MUKUND P. · 2012 to 2016
$4.9M
Structural basis of sigma-regulator recognition by a site-1 protease during cell surface signaling by Gram-negative bacteria.R01GM126207 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Christopher L Colbert · 2018 to 2026
$1.7M
Molecular mechanism by which Epstein-Barr Virus-encoded BHRF1 blocks BECN1-mediated autophagyR15GM146232 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI HERSHBERGER, JOHN F · 2022 to 2023
$535k
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
Elucidating the structural basis of differential interactions of human BECN paralogs and their role in cellular homeostasisR15GM122035 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI SINHA, SANGITA · 2017 to 2017
$435k
Intrinsically Disordered Regions in Autophagy ProteinsR03NS090939 · NINDS · NORTH DAKOTA STATE UNIVERSITY · PI SINHA, SANGITA · 2014 to 2015
$145k
NIGMS NIH HHS P30 GM103332NIGMS NIH HHS P30 GM138395NIGMS NIH HHS R01 GM126207NIGMS NIH HHS R15 GM122035NIGMS NIH HHS R15 GM146232NIH HHS S10 OD018090NINDS NIH HHS R03 NS090939
6 · The paper itself

Abstract

abbreviationsAFM: aromatic finger mutant; BH3D: BCL2 homology 3 domain; CCD: coiled-coil domain; CD: circular dichroism spectroscopy; [CysDM1]: C18S and C21S double mutant; [CysDM2]: C137S, and C140S double mutant; [CysTM], C18S, C21S, C137S, and C140S tetrad mutant; D

Indexed as

AutophagyZincProtein DomainsScattering, Small AngleX-Ray DiffractionZincAutophagyBECN1 (Beclin 1)conformational transitionsintrinsically disordered region (IDR)invariant CxxC motifsZn2+-binding

Identifiers

PMID37791766
PMCPMC10813572

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.