Evidence map›Paper›PMID 37792156›Full record

SynthesisEndocrine pathology2023

Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence.

Rayan Rammal, Jason K Wasserman, Aatur D Singhi, Christopher C Griffith, Raja R Seethala

Abstract readMeta-AnalysisSystematic ReviewCase Reports
PubMed Publisher
In one paragraph

Synthesis in Endocrine pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rayan RammalDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. rammalr@upmc.edu.
Jason K WassermanDepartment of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Christopher C GriffithDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Raja R SeethalaDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
University of Pittsburgh Medical Center · USCleveland Clinic · USOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaplastic thyroid carcinoma (ATC) demonstrates a wide variety of morphologies and is characteristically associated with a differentiated thyroid carcinoma component. Heterologous differentiation is a rare, potentially challenging phenomenon in ATC, mostly observed as osteosarcomatous or chondrosarcomatous differentiation. We now describe a novel 'glomangiosarcoma-like' differentiation, review our archival experience from two institutions (UPMC, CC), and perform a systematic review for the prevalence of heterologous elements in ATC. The patient is a 57-year-old female who presented with 4.5 cm left thyroid, and 3.4 cm neck masses. Histologically, the thyroid demonstrated a differentiated high grade papillary thyroid carcinoma, tall cell and hobnail/micropapillary subtypes transitioning into an anaplastic component with spindled to ovoid cells with hemangiopericytoma-like vasculature showing CD34 positivity, variable muscle marker expression and pericellular lace-like type IV collagen deposition. The neck mass consisted solely of the latter morphology. Targeted next-generation sequencing was performed on high grade DTC and adjacent ATC from the thyroid as well as ATC from the neck metastasis. All three components shared BRAF

Indexed as

AdenocarcinomaSarcomaThyroid Carcinoma, AnaplasticThyroid NeoplasmsCell DifferentiationFemaleHumansMiddle AgedPrevalenceProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryProto-Oncogene Proteins B-rafAnaplasticDifferentiatedGlomangiosarcomaHeterologousHigh gradePapillary thyroid carcinoma

Identifiers

PMID37792156
OpenAlexW4387326169

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.