Evidence mapPaperPMID 37794113Full record

ArticleCommunications medicine2023

Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review.

Laura M Jacobsen, Jennifer L Sherr, Elizabeth Considine, Angela Chen, Sarah M Peeling, Margo Hulsmans, Sara Charleer, Marzhan Urazbayeva, Mustafa Tosur, Selma Alamarie and 10 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07461805 (Caracterización de Subgrupos de Personas Con Diabetes Tipo 1), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07461805 recruitingnot on this mapstarted 2025, after this paper: background citation

Caracterización de Subgrupos de Personas Con Diabetes Tipo 1: análisis de características clínicas y glucométricas Utilizando Una aproximación de Inteligencia Artificial

Typeobservational_patient_registrySponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2025 to 2028Enrolled800ConditionsType 1 Diabetes Mellitus
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Proposed Practical Guidelines to Improve Glycaemic Management by Reducing Glycaemic Variability in People with Type 1 Diabetes Mellitus.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 20 institutions in 26 countries.

Laura M Jacobsen *University of Florida, Gainesville, FL, USA.
Jennifer L Sherr *Yale School of Medicine, New Haven, CT, USA.
Elizabeth ConsidineYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1023-8939
Angela ChenUniversity of Florida, Gainesville, FL, USA.
Sarah M PeelingUniversity of Florida, Gainesville, FL, USA.
Margo HulsmansUniversity Hospital Leuven, Leuven, Belgium.
Sara CharleerUniversity Hospital Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2100-4927
Marzhan UrazbayevaBaylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Mustafa TosurBaylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.ORCID http://orcid.org/0000-0002-2111-271X
Selma AlamarieStanford University School of Medicine, Stanford, CA, USA.
Maria J RedondoBaylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Korey K HoodStanford University School of Medicine, Stanford, CA, USA.
Peter A GottliebBarbara Davis Center, University of Colorado School of Medicine, Aurora, CO, USA.
Pieter GillardUniversity Hospital Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9111-4561
Jessie J WongChildren's Nutrition Research Center, USDA/ARS, Houston, TX, USA.ORCID http://orcid.org/0000-0003-2093-4647
Irl B HirschUniversity of Washington School of Medicine, Seattle, WA, USA.
Richard E PratleyAdventHealth Translational Research Institute, Orlando, FL, USA.
Lori M LaffelJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Chantal MathieuUniversity Hospital Leuven, Leuven, Belgium. chantal.mathieu@uzleuven.be.
ADA/EASD PMDI
Johns Hopkins University · USUniversity of Copenhagen · DKBroad Institute · USHarvard University · USNorthwestern University · USUniversity of Exeter · GBUniversity of Dundee · GBBaylor College of Medicine · USChinese University of Hong Kong · HKLund University · SEBrigham and Women's Hospital · USNational Institutes of Health · USUniversity of Maryland, Baltimore · USUniversity of South Dakota · USHôpital Necker-Enfants Malades · FRIndiana University School of MedicineJoslin Diabetes Center · USUniversity of Chicago · USUniversity of Florida · USUniversity of Pittsburgh · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6M
PILOT STUDY--SECRETORY TARGETING IN PANCREATIC B CELLSP30DK036836 · JOSLIN DIABETES CENTER · 1986 to 2025
$12.1M
Yale Diabetes Research CenterP30DK045735 · YALE UNIVERSITY · 1993 to 2025
$10.2M
Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
Stanford Islet Research CoreP30DK116074 · STANFORD UNIVERSITY · 2025 to 2025
$2.0M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$1.3M
Family Matters: Optimizing Family-Based Interventions for Adolescents with Type 1 DiabetesK23DK121771 · NIDDK · STANFORD UNIVERSITY · PI Jessie J. Wong · 2023 to 2024
$324k
Investigation of Arginine Metabolism and Its Effects on Beta Cell Function in Children with Type 2 DiabetesK23DK129821 · BAYLOR COLLEGE OF MEDICINE · 2025 to 2025
$185k
Development of a Predictive Response Signature to Anti-Thymocyte Globulin in Type 1 DiabetesK08DK128628 · UNIVERSITY OF FLORIDA · 2025 to 2025
$119k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K08 DK128628NIDDK NIH HHS K23 DK121771NIDDK NIH HHS K23 DK129821NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK116073NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK121843Wellcome Trust 210752/Z/18/Z
6 · The paper itself

Abstract

backgroundThe greatest change in the treatment of people living with type 1 diabetes in the last decade has been the explosion of technology assisting in all aspects of diabetes therapy, from glucose monitoring to insulin delivery and decision making. As such, the aim of our systematic review was to assess the utility of these technologies as well as identify any precision medicine-directed findings to personalize care.

methodsScreening of 835 peer-reviewed articles was followed by systematic review of 70 of them (focusing on randomized trials and extension studies with ≥50 participants from the past 10 years).

resultsWe find that novel technologies, ranging from continuous glucose monitoring systems, insulin pumps and decision support tools to the most advanced hybrid closed loop systems, improve important measures like HbA1c, time in range, and glycemic variability, while reducing hypoglycemia risk. Several studies included person-reported outcomes, allowing assessment of the burden or benefit of the technology in the lives of those with type 1 diabetes, demonstrating positive results or, at a minimum, no increase in self-care burden compared with standard care. Important limitations of the trials to date are their small size, the scarcity of pre-planned or powered analyses in sub-populations such as children, racial/ethnic minorities, people with advanced complications, and variations in baseline glycemic levels. In addition, confounders including education with device initiation, concomitant behavioral modifications, and frequent contact with the healthcare team are rarely described in enough detail to assess their impact.

conclusionsOur review highlights the potential of technology in the treatment of people living with type 1 diabetes and provides suggestions for optimization of outcomes and areas of further study for precision medicine-directed technology use in type 1 diabetes.

Identifiers

PMID37794113
PMCPMC10550996
OpenAlexW4387345344

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.