Evidence map›Paper›PMID 37794121›Full record

ReviewNature reviews. Neuroscience2023

Reconstructing computational system dynamics from neural data with recurrent neural networks.

Daniel Durstewitz, Georgia Koppe, Max Ingo Thurm

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 101 citations in OpenAlex.

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  8. Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Predictive pursuit emerges in high-dimensional recurrent neural networks.bioRxiv : the preprint server for biology · 2026
    Article
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  11. Re-engineering the disordered mind: clinical experimentation, dynamical systems, and AI for personalized psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  12. Article
  13. Review
  14. Endometrial immune dysregulation shapes CD8Frontiers in immunology · 2026
    Article
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  17. WhenAPL bioengineering · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daniel DurstewitzDept. of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. daniel.durstewitz@zi-mannheim.de.ORCID http://orcid.org/0000-0002-9340-3786
Georgia KoppeDept. of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-2941-9238
Max Ingo ThurmDept. of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computational models in neuroscience usually take the form of systems of differential equations. The behaviour of such systems is the subject of dynamical systems theory. Dynamical systems theory provides a powerful mathematical toolbox for analysing neurobiological processes and has been a mainstay of computational neuroscience for decades. Recently, recurrent neural networks (RNNs) have become a popular machine learning tool for studying the non-linear dynamics of neural and behavioural processes by emulating an underlying system of differential equations. RNNs have been routinely trained on similar behavioural tasks to those used for animal subjects to generate hypotheses about the underlying computational mechanisms. By contrast, RNNs can also be trained on the measured physiological and behavioural data, thereby directly inheriting their temporal and geometrical properties. In this way they become a formal surrogate for the experimentally probed system that can be further analysed, perturbed and simulated. This powerful approach is called dynamical system reconstruction. In this Perspective, we focus on recent trends in artificial intelligence and machine learning in this exciting and rapidly expanding field, which may be less well known in neuroscience. We discuss formal prerequisites, different model architectures and training approaches for RNN-based dynamical system reconstructions, ways to evaluate and validate model performance, how to interpret trained models in a neuroscience context, and current challenges.

Indexed as

Artificial IntelligenceNeurosciencesAnimalsHumansNeural Networks, Computer

Identifiers

PMID37794121
OpenAlexW4387343609

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.