Evidence map›Paper›PMID 37794239›Full record

ReviewNature reviews. Immunology2024

The effect of physical exercise on anticancer immunity.

Carmen Fiuza-Luces, Pedro L Valenzuela, Beatriz G Gálvez, Manuel Ramírez, Alejandro López-Soto, Richard J Simpson, Alejandro Lucia

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 98 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  20. Cellular senescence and aging: molecular mechanisms and convergent pathways.Cellular and molecular life sciences : CMLS · 2026
    Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Carmen Fiuza-LucesPhysical Activity and Health Research Group ('PaHerg'), Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain. cfiuza.imas12@h12o.es.ORCID http://orcid.org/0000-0001-8131-7007
Pedro L ValenzuelaPhysical Activity and Health Research Group ('PaHerg'), Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain.
Beatriz G GálvezPhysical Activity and Health Research Group ('PaHerg'), Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain.ORCID http://orcid.org/0000-0002-8082-9323
Manuel RamírezOncohematology Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Alejandro López-SotoDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain. lopezsalejandro@uniovi.es.
Richard J SimpsonSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ, USA.
Alejandro LuciaCIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain. alejandro.lucia@universidadeuropea.es.ORCID http://orcid.org/0000-0002-5565-0997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular physical activity is associated with lower cancer incidence and mortality, as well as with a lower rate of tumour recurrence. The epidemiological evidence is supported by preclinical studies in animal models showing that regular exercise delays the progression of cancer, including highly aggressive malignancies. Although the mechanisms underlying the antitumorigenic effects of exercise remain to be defined, an improvement in cancer immunosurveillance is likely important, with different immune cell subtypes stimulated by exercise to infiltrate tumours. There is also evidence that immune cells from blood collected after an exercise bout could be used as adoptive cell therapy for cancer. In this Perspective, we address the importance of muscular activity for maintaining a healthy immune system and discuss the effects of a single bout of exercise (that is, 'acute' exercise) and those of 'regular' exercise (that is, repeated bouts) on anticancer immunity, including tumour infiltrates. We also address the postulated mechanisms and the clinical implications of this emerging area of research.

Indexed as

ExerciseNeoplasmsAnimalsHumansImmune System

Identifiers

PMID37794239

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.