Evidence map›Paper›PMID 37794253›Full record

ReviewNature medicine2023

Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.

Deirdre K Tobias, Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L Benham, Dhanasekaran Bodhini, Amy L Clark, Kevin Colclough, Rosa Corcoy, Sara J Cromer and 190 more

Registry-linked trialAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07461805 (Caracterización de Subgrupos de Personas Con Diabetes Tipo 1), which is not on this map. Cited by 139 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07461805 recruitingnot on this mapstarted 2025, after this paper: background citation

Caracterización de Subgrupos de Personas Con Diabetes Tipo 1: análisis de características clínicas y glucométricas Utilizando Una aproximación de Inteligencia Artificial

Typeobservational_patient_registrySponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2025 to 2028Enrolled800ConditionsType 1 Diabetes Mellitus
3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Prognostic models for all-cause and cardiovascular mortality in type 2 diabetes: Systematic review.Diabetic medicine : a journal of the British Diabetic Association · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Metabolic dysfunction and the use of adjunct medications in type 1 diabetes.Current opinion in endocrinology, diabetes, and obesity · 2026
    Review
  15. Glycemic response trajectories on metformin monotherapy in real-world diabetes care.medRxiv : the preprint server for health sciences · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. New Personalized Medicine Model for Medication Management.Journal of personalized medicine · 2026
    Review
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

200 authors.

Deirdre K Tobias *Division of Preventative Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jordi Merino *Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abrar Ahmad *Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Catherine Aiken *Department of Obstetrics and Gynaecology, The Rosie Hospital, Cambridge, UK.
Jamie L Benham *Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dhanasekaran Bodhini *Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India.ORCID 0000-0001-7194-0639
Amy L ClarkDivision of Pediatric Endocrinology, Department of Pediatrics, Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children's Hospital, St. Louis, MO, USA.
Kevin Colclough *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Rosa CorcoyCIBER-BBN, ISCIII, Madrid, Spain.
Sara J Cromer *Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
Daisy Duan *Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4392-3206
Jamie L Felton *Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Ellen C Francis *Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Pieter Gillard *University Hospital Leuven, Leuven, Belgium.
Véronique Gingras *Department of Nutrition, Université de Montréal, Montreal, Quebec, Quebec, Canada.
Romy Gaillard *Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands.
Eram Haider *Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.
Alice Hughes *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0003-1352-4447
Jennifer M Ikle *Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Laura M Jacobsen *University of Florida, Gainesville, FL, USA.
Anna R Kahkoska *Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jarno L T Kettunen *Helsinki University Hospital, Abdominal Centre/Endocrinology, Helsinki, Finland.ORCID 0000-0002-9995-698X
Raymond J Kreienkamp *Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
Lee-Ling Lim *Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jonna M E Männistö *Departments of Pediatrics and Clinical Genetics, Kuopio University Hospital, Kuopio, Finland.
Robert Massey *Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.
Niamh-Maire Mclennan *Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Rachel G MillerDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1845-8477
Mario Luca Morieri *Metabolic Disease Unit, University Hospital of Padova, Padova, Italy.
Jasper Most *Department of Orthopedics, Zuyderland Medical Center, Sittard-Geleen, The Netherlands.
Rochelle N Naylor *Departments of Pediatrics and Medicine, University of Chicago, Chicago, IL, USA.
Bige Ozkan *Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kashyap Amratlal Patel *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0002-9240-8104
Scott J Pilla *Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Katsiaryna Prystupa *Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Sridharan Raghavan *Section of Academic Primary Care, US Department of Veterans Affairs Eastern Colorado Health Care System, Aurora, CO, USA.
Mary R Rooney *Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Martin Schön *Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Zhila Semnani-Azad *Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Magdalena Sevilla-Gonzalez *Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.
Pernille Svalastoga *Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Wubet Worku Takele *Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia.
Claudia Ha-Ting Tam *Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-9169-0013
Anne Cathrine B Thuesen *Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mustafa Tosur *Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Amelia S Wallace *Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Caroline C Wang *Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jessie J Wong *Stanford University School of Medicine, Stanford, CA, USA.
Jennifer M Yamamoto *Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Katherine Young *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Chloé AmouyalDepartment of Diabetology, APHP, Paris, France.
Mette K AndersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Maxine P BonhamDepartment of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia.
Mingling ChenMonash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia.
Feifei ChengHealth Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Tinashe ChikoworeDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Sian C ChiversDepartment of Women and Children's Health, King's College London, London, UK.
Christoffer ClemmensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2456-9667
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Adem Y DawedDivision of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0003-0224-2428
Aaron J DeutschCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6750-5335
Laura T DickensSection of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, University of Chicago, Chicago, IL, USA.
Linda A DiMeglioDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-8033-6078
Monika Dudenhöffer-PfeiferDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Carmella Evans-MolinaDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0001-7764-8663
María Mercè Fernández-BalsellsBiomedical Research Institute Girona, IdIBGi, Girona, Spain.
Hugo FitipaldiDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Stephanie L FitzpatrickInstitute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Stephen E GitelmanUniversity of California at San Francisco, Department of Pediatrics, Diabetes Center, San Francisco, CA, USA.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-6364-5103
Jessica A GriegerAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Marta Guasch-FerréDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nahal HabibiAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Chuiguo HuangDepartment of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.
Arianna Harris-KawanoDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Heba M IsmailDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Benjamin HoagDivision of Endocrinology and Diabetes, Department of Pediatrics, Sanford Children's Hospital, Sioux Falls, SD, USA.
Randi K JohnsonDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Angus G JonesDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0002-0883-7599
Robert W KoivulaOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Aaron LeongDiabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
Gloria K W LeungDepartment of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia.
Ingrid M LibmanUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Kai LiuAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
S Alice LongCenter for Translational Immunology, Benaroya Research Institute, Seattle, WA, USA.ORCID 0000-0002-0281-1240
William L LoweDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-9467-3422
Robert W MortonDepartment of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Ayesha A MotalaDepartment of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Suna Onengut-GumuscuCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-6563-8334
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7076-483X
Maleesa PathiranaAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Sofia PazminoDepartment of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium.
Dianna PerezDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
John R PetrieSchool of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Camille E PoweDiabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.
Alejandra QuinterosAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Rashmi JainSanford Children's Specialty Clinic, Sioux Falls, SD, USA.
Debashree RayDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-0979-2935
Mathias Ried-LarsenCentre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-8388-5291
Zeb SaeedDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Indiana University School of Medicine, Indianapolis, IN, USA.
Vanessa SanthakumarDivision of Preventative Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sarah KanbourDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Sudipa SarkarDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Gabriela S F MonacoDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Denise M ScholtensDepartment of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-8252-7863
Elizabeth SelvinWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-3539-2070
Wayne Huey-Herng SheuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.
Cate SpeakeCenter for Interventional Immunology, Benaroya Research Institute, Seattle, WA, USA.ORCID 0000-0003-1480-4272
Maggie A StanislawskiDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Nele SteenackersDepartment of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium.
Andrea K SteckBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Norbert StefanGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-2186-9595
Julie StøySteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Rachael TaylorUniversity of Newcastle, Newcastle upon Tyne, UK.
Sok Cin TyeSections on Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Gebresilasea Gendisha UkkeEastern Health Clinical School, Monash University, Melbourne, Victoria, Australia.
Marzhan UrazbayevaDivision of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA.
Bart Van der SchuerenDepartment of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium.
Camille VatierSorbonne University, Inserm U938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, Paris, France.
John M WentworthRoyal Melbourne Hospital Department of Diabetes and Endocrinology, Parkville, Victoria, Australia.
Wesley HannahDeakin University, Melbourne, Victoria, Australia.
Sara L WhiteDepartment of Women and Children's Health, King's College London, London, UK.
Gechang YuDepartment of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.
Yingchai ZhangDepartment of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.
Shao J ZhouRobinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
Jacques BeltrandInstitut Cochin, Inserm U 10116, Paris, France.
Michel PolakInstitut Cochin, Inserm U 10116, Paris, France.
Ingvild AukrustMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Elisa de FrancoDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Sarah E FlanaganDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Kristin A MaloneyDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8607-1146
Andrew McGovernDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Janne MolnesMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Mariam NakabuyeNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pål Rasmus NjølstadMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-0304-6728
Hugo Pomares-MillanDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Michele ProvenzanoNephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Cécile Saint-MartinDepartment of Medical Genetics, AP-HP Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Cuilin ZhangGlobal Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yeyi ZhuKaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Sungyoung AuhNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Russell de SouzaPopulation Health Research Institute, Hamilton, Ontario, Canada.
Andrea J FawcettAnn & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Chandra GruberAmerican Diabetes Association, Arlington, VA, USA.
Eskedar Getie MekonnenCollege of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Emily MixterDepartment of Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA.
Diana SherifaliPopulation Health Research Institute, Hamilton, Ontario, Canada.
Robert H EckelDivision of Endocrinology, Metabolism, Diabetes, University of Colorado, Aurora, CO, USA.
John J NolanDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Louis H PhilipsonDepartment of Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA.
Rebecca J Brown *National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Liana K Billings *Division of Endocrinology, NorthShore University HealthSystem, Skokie, IL, USA.
Kristen Boyle *Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9689-3322
Tina CostacouDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
John M Dennis *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0002-7171-732X
Jose C Florez *Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1730-9325
Anna L Gloyn *Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1205-1844
Maria F Gomez *Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.ORCID 0000-0001-6210-3142
Peter A Gottlieb *Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Siri Atma W Greeley *Departments of Pediatrics and Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA.
Kurt Griffin *Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA.
Andrew T Hattersley *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0001-5620-473X
Irl B Hirsch *University of Washington School of Medicine, Seattle, WA, USA.
Marie-France Hivert *Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7752-2585
Korey K Hood *Stanford University School of Medicine, Stanford, CA, USA.
Jami L Josefson *Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Soo Heon Kwak *Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0003-1230-0919
Lori M Laffel *Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Siew S Lim *Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia.
Ruth J F Loos *Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ronald C W Ma *Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-1227-803X
Chantal Mathieu *University Hospital Leuven, Leuven, Belgium.
Nestoras Mathioudakis *Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
James B Meigs *Department of Medicine, Harvard Medical School, Boston, MA, USA.
Shivani Misra *Division of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0003-2886-0726
Viswanathan Mohan *Department of Diabetology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India.ORCID 0000-0001-5038-6210
Rinki Murphy *Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-0043-2423
Richard Oram *Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0003-3581-8980
Katharine R Owen *Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.ORCID 0000-0003-3982-1407
Susan E Ozanne *University of Cambridge, Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Cambridge, UK.ORCID 0000-0001-8753-5144
Ewan R Pearson *Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0001-9237-8585
Wei Perng *Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Toni I Pollin *Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Rodica Pop-BusuiDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
Richard E Pratley *AdventHealth Translational Research Institute, Orlando, FL, USA.
Leanne M Redman *Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Maria J Redondo *Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Rebecca M Reynolds *Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Robert K Semple *Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-6539-3069
Jennifer L Sherr *Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9301-3043
Emily K Sims *Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-4393-954X
Arianne Sweeting *Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Tiinamaija Tuomi *Helsinki University Hospital, Abdominal Centre/Endocrinology, Helsinki, Finland.ORCID 0000-0002-8306-6202
Miriam S Udler *Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-3824-9162
Kimberly K Vesco *Kaiser Permanente Northwest, Kaiser Permanente Center for Health Research, Portland, OR, USA.
Tina Vilsbøll *Clinial Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.
Robert Wagner *Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-6120-0191
Stephen S Rich *Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Paul W Franks *Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. paul.franks@med.lu.se.ORCID 0000-0002-0520-7604

Funding

Data Coordinating Center for Type 1 Diabetes TrialNetU01DK106993 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · 2022 to 2025
$43.4M
PILOT STUDY--SECRETORY TARGETING IN PANCREATIC B CELLSP30DK036836 · JOSLIN DIABETES CENTER · 1986 to 2025
$12.1M
RADIANT Clinic and Data Coordinating CenterU54DK118612 · NIDDK · UNIVERSITY OF CHICAGO · 2022 to 2025
$8.2M
Clinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research CollaborativeUG1HD107691 · NICHD · TUFTS UNIVERSITY BOSTON · 2023 to 2025
$7.2M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · MASSACHUSETTS GENERAL HOSPITAL · 1994 to 2025
$6.0M
Pilot & Feasibility ProgramP30DK063491 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2003 to 2025
$5.4M
TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · MASSACHUSETTS GENERAL HOSPITAL · 1986 to 2025
$4.2M
Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)K12DK133995 · STANFORD UNIVERSITY · 2025 to 2025
$3.7M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · JOHNS HOPKINS UNIVERSITY · 1985 to 2025
$3.7M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1986 to 2005
$3.5M
TOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · 2022 to 2025
$3.1M
Pilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2M
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6 · The paper itself

Abstract

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.

Indexed as

Diabetes MellitusPrecision MedicineEvidence-Based MedicineHumans

Identifiers

PMID37794253
PMCPMC10735053

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.