Evidence map›Paper›PMID 37794255›Full record

ArticleArchives of toxicology2023

Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells.

Yuxi Li, Xilin Li, Patrick Cournoyer, Supratim Choudhuri, Lei Guo, Si Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  5. NAD(P)Archives of toxicology · 2025
    Article
  6. Review
  7. Article
  8. The impact of cannabinoids on reproductive function.Reproduction (Cambridge, England) · 2025
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuxi LiDivision of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA.
Xilin LiDivision of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Patrick CournoyerOffice of the Commissioner, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA.
Supratim ChoudhuriOffice of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.
Lei GuoDivision of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA.
Si ChenDivision of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Si.Chen@fda.hhs.gov.ORCID http://orcid.org/0000-0002-8872-311X
National Center for Toxicological Research · USCenter for Food Safety and Applied Nutrition · USUnited States Food and Drug Administration · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Cannabidiol (CBD) is one of the most prevalent and abundant cannabinoids extracted from the plant Cannabis sativa. CBD has been reported to induce male reproductive toxicity in animal models. In this study, we examined the effects of CBD and its main metabolites, 7-carboxy-CBD and 7-hydroxy-CBD, on primary human Leydig cells, which play a crucial role in male reproductive health. Our results showed that CBD, at concentrations below the Bayesian benchmark dose (BMD)

Indexed as

CannabidiolCannabinoidsAnimalsApoptosisBayes TheoremHumansLeydig CellsMaleCannabidiolCannabinoids7-Carboxy-CBD7-Hydroxy-CBDApoptosisCannabidiolCell cycle arrestDNA synthesisLeydig cellsMale reproductive toxicity

Identifiers

PMID37794255
PMCPMC11404726
OpenAlexW4387327818

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.