Evidence map›Paper›PMID 37794420›Full record

ArticleArthritis research & therapy2023

Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy.

Matthew Wright, Mette Kiel Smed, J Lee Nelson, Jørn Olsen, Merete Lund Hetland, Nicholas P Jewell, Vibeke Zoffmann, Damini Jawaheer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Matthew WrightChildren's Hospital Oakland Research Institute, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-6634-934X
Mette Kiel SmedJuliane Marie Centeret, Rigshospitalet, Copenhagen, Denmark.
J Lee NelsonFred Hutchinson Cancer Center, Seattle, WA, USA.
Jørn OlsenUniversity of California Los Angeles, Los Angeles, CA, USA.
Merete Lund HetlandDANBIO Registry and Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.
Nicholas P JewellLondon School of Hygiene and Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-8637-9132
Vibeke ZoffmannJuliane Marie Centeret, Rigshospitalet, Copenhagen, Denmark.
Damini JawaheerChildren's Hospital Oakland Research Institute, Oakland, CA, USA. Damini.Jawaheer@northwestern.edu.ORCID https://orcid.org/0000-0003-4954-874X
Northwestern University · USUniversity of Copenhagen · DKLondon School of Hygiene & Tropical Medicine · GBRigshospitalet · DKUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

The Pregnancy Transcriptome in Rheumatoid Arthritis - RenewalR01AR073111 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Damini Jawaheer · 2017 to 2026
$4.6M
Emerging methods and applications for test-negative studies of of infectious disease interventionsR01AI148127 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI JEWELL, NICHOLAS P · 2020 to 2023
$1.8M
Gene Expression Profiling in a Prospective Rheumatoid Arthritis Pregnancy CohortR21AR057931 · NIAMS · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI JAWAHEER, DAMINI · 2010 to 2011
$334k
NIAID NIH HHS R01 AI148127NIAMS NIH HHS R01 AR073111NIAMS NIH HHS R21 AR057931
6 · The paper itself

Abstract

backgroundWhile many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this improvement or worsening. In our unique RA pregnancy cohort that includes a pre-pregnancy baseline, we have examined pre-pregnancy gene co-expression networks to identify differences between women with RA who subsequently improve during pregnancy and those who worsen.

methodsBlood samples were collected before pregnancy (T0) from 19 women with RA and 13 healthy women enrolled in our prospective pregnancy cohort. RA improvement/worsening between T0 and 3rd trimester was assessed by changes in the Clinical Disease Activity Index (CDAI). Pre-pregnancy expression profiles were examined by RNA sequencing and differential gene expression analysis. Weighted gene co-expression network analysis (WGCNA) was used to identify co-expression modules correlated with the improvement/worsening of RA during pregnancy and to assess their functional relevance.

resultsOf the 19 women with RA, 14 improved during pregnancy (RA

conclusionThe pre-pregnancy gene expression signatures identified represent potential biomarkers to predict the subsequent improvement/worsening of RA during pregnancy, which has important implications for the personalized treatment of RA during pregnancy.

Indexed as

Arthritis, RheumatoidTranscriptomeBiomarkersFemaleGene Expression ProfilingHumansPregnancyProspective StudiesBiomarkersCo-expression network analysisGene expressionPregnancyPre-pregnancy biomarkersRheumatoid arthritisRNA sequencing (RNA-seq)

Identifiers

PMID37794420
PMCPMC10548620
OpenAlexW4387336744

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.