Evidence map›Paper›PMID 37796127›Full record

ArticleJournal of virology2023

Insulin-mediated endothelin signaling is antiviral during West Nile virus infection.

Chasity E Trammell, Evelyn H Rowe, Aditya B Char, Brianne J Jones, Stephen Fawcett, Laura R H Ahlers, Alan G Goodman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Frontiers in microbiology · 2024
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chasity E TrammellSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University , Pullman, Washington, USA.ORCID 0000-0002-1698-883X
Evelyn H RoweSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University , Pullman, Washington, USA.
Aditya B CharSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University , Pullman, Washington, USA.
Brianne J JonesSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University , Pullman, Washington, USA.
Stephen FawcettSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University , Pullman, Washington, USA.
Laura R H AhlersRNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland, USA.
Alan G GoodmanSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University , Pullman, Washington, USA.ORCID 0000-0001-6394-332X
Washington State University · USNational Institutes of Health · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Exploiting a cyclic dinucleotide-mediated immune response to reduce the burden of Coxiella burnetii infectionR01AI139051 · NIAID · WASHINGTON STATE UNIVERSITY · PI GOODMAN, ALAN GABRIEL · 2019 to 2023
$2.4M
NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

importanceArboviruses, particularly those transmitted by mosquitoes, pose a significant threat to humans and are an increasing concern because of climate change, human activity, and expanding vector-competent populations. West Nile virus is of significant concern as the most frequent mosquito-borne disease transmitted annually within the continental United States. Here, we identify a previously uncharacterized signaling pathway that impacts West Nile virus infection, namely endothelin signaling. Additionally, we demonstrate that we can successfully translate results obtained from

Indexed as

EndothelinsInsulinWest Nile FeverAnimalsDrosophila melanogasterHumansSignal TransductionWest Nile virusEndothelinsInsulinAKTCG43775Drosophila melanogasterimmunityRNA sequencing

Identifiers

PMID37796127
PMCPMC10617537
OpenAlexW4387364981

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.