Evidence map›Paper›PMID 37799377›Full record

ArticleActa pharmaceutica Sinica. B2023

Cathepsin D overexpression in the nervous system rescues lethality and A

Xiaosen Ouyang, Willayat Y Wani, Gloria A Benavides, Matthew J Redmann, Hai Vo, Thomas van Groen, Victor M Darley-Usmar, Jianhua Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaosen OuyangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Willayat Y WaniDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gloria A BenavidesDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Matthew J RedmannDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Hai VoDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Thomas van GroenDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Victor M Darley-UsmarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jianhua ZhangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · US

Funding

Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
Alabama Neuroscience Blueprint Core CenterP30NS057098 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROTH, KEVIN A · 2006 to 2010
$9.5M
UAB Neuroscience Core CenterP30NS047466 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS · 2005 to 2019
$8.5M
Mechanisms of Impaired Lysosomal Biogenesis and Autophagy in Alcohol-Associated Alzheimer's DiseaseR01AG072895 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING · 2020 to 2024
$1.9M
Alpha-synuclein degradation mechanismsR01NS064090 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, JIANHUA · 2010 to 2014
$1.6M
Lysosomal enhancement strategies in dopaminergic neurodegenerationR21NS101672 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, JIANHUA · 2017 to 2018
$408k
O-GlcNAc regulation of protein clearance in the context of AD and DLBR56AG060959 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, ZHANG, JIANHUA · 2019 to 2019
$371k
BLRD VA I01 BX004251NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG072895NIA NIH HHS R56 AG060959NINDS NIH HHS P30 NS047466NINDS NIH HHS P30 NS057098NINDS NIH HHS R01 NS064090NINDS NIH HHS R21 NS101672
6 · The paper itself

Abstract

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans lead to neurolipofuscinosis (NCL) and is important in removing toxic protein aggregates. Prior studies demonstrated that CTSD germ-line knockout-

Indexed as

ApoptosisAutophagyBehaviorCathepsin D knockout miceCathepsin D transgenic mouseDopamineLife expectancyLysosomeMitochondrial bioenergeticsNeuronal ceroid lipofuscinosis

Identifiers

PMID37799377
PMCPMC10547960
OpenAlexW4384936975

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.