Evidence map›Paper›PMID 37799579›Full record

ArticleRSC chemical biology2023

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk.

Wenyuan Zhou, Amy Ryan, Chasity P Janosko, Karsen E Shoger, Jason M Haugh, Rachel A Gottschalk, Alexander Deiters

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wenyuan ZhouDepartment of Chemistry, University of Pittsburgh Pittsburgh PA 15260 USA deiters@pitt.edu.
Amy RyanDepartment of Chemistry, University of Pittsburgh Pittsburgh PA 15260 USA deiters@pitt.edu.
Chasity P JanoskoDepartment of Chemistry, University of Pittsburgh Pittsburgh PA 15260 USA deiters@pitt.edu.
Karsen E ShogerDepartment of Immunology, University of Pittsburgh School of Medicine Pittsburgh PA 15260 USA.
Jason M HaughDepartment of Chemical and Biomolecular Engineering, North Carolina State University Raleigh NC 27606 USA.
Rachel A GottschalkDepartment of Immunology, University of Pittsburgh School of Medicine Pittsburgh PA 15260 USA.
Alexander DeitersDepartment of Chemistry, University of Pittsburgh Pittsburgh PA 15260 USA deiters@pitt.edu.ORCID https://orcid.org/0000-0003-0234-9209
University of Pittsburgh · USNorth Carolina State University · US

Funding

"On the Fly" Time Resolved Cryo-EM Studies of Intermediate HIV-1 RT Transition StatesR01AI175067 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Guillermo Alberto Calero, Alexander Deiters · 2022 to 2026
$3.8M
Quantitative control of phosphorylation and mechanistic links to immune cell decisionsR35GM146896 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Rachel A Gottschalk · 2022 to 2026
$2.0M
NIAID NIH HHS R01 AI175067NIGMS NIH HHS R35 GM146896
6 · The paper itself

Abstract

Evolution has diversified the mammalian proteome by the generation of protein isoforms that originate from identical genes,

Identifiers

PMID37799579
PMCPMC10549237
OpenAlexW4386174169

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.