Evidence map›Paper›PMID 37800576›Full record

ReviewGut microbes2023

Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values.

Yu Wang, Yusheng Li, Lin Bo, Enyuan Zhou, Yanyan Chen, Shinen Naranmandakh, Wenqing Xie, Qin Ru, Lin Chen, Zhaohua Zhu and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. ProbioticGut microbes · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. The oral-gut-joint axis in osteoarthritis: a multiomics case-control study.Frontiers in cellular and infection microbiology · 2026
    Observational
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Yu WangDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Yusheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Lin BoDepartment of Rheumatology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Enyuan ZhouDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Yanyan ChenDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.
Shinen NaranmandakhSchool of Arts and Sciences, National University of Mongolia, Ulaanbaatar, Mongolia.
Wenqing XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Qin RuDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.ORCID 0000-0002-2169-7471
Lin ChenDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.ORCID 0000-0002-1005-1202
Zhaohua ZhuClinical Research Centre, Orthopedic Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Changhai DingClinical Research Centre, Orthopedic Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yuxiang WuDepartment of Health and Kinesiology, School of Physical Education, Jianghan University, Wuhan, China.ORCID 0000-0002-9041-4471
Jianghan University · CNCentral South University · CNNational University of Mongolia · MNSoochow University · CNUniversity of Tasmania · AUZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The musculoskeletal system is important for balancing metabolic activity and maintaining health. Recent studies have shown that distortions in homeostasis of the intestinal microbiota are correlated with or may even contribute to abnormalities in musculoskeletal system function. Research has also shown that the intestinal flora and its secondary metabolites can impact the musculoskeletal system by regulating various phenomena, such as inflammation and immune and metabolic activities. Most of the existing literature supports that reasonable nutritional intervention helps to improve and maintain the homeostasis of intestinal microbiota, and may have a positive impact on musculoskeletal health. The purpose of organizing, summarizing and discussing the existing literature is to explore whether the intervention methods, including nutritional supplement and moderate exercise, can affect the muscle and bone health by regulating the microecology of the intestinal flora. More in-depth efficacy verification experiments will be helpful for clinical applications.

Indexed as

Gastrointestinal MicrobiomeHomeostasisHumansInflammationinfluenceintervention methodsIntestinal microbiotamechanismmusculoskeletal system

Identifiers

PMID37800576
PMCPMC10561578
OpenAlexW4387392211

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.