ArticleScientific reports2023
Association between number of medications and hip fractures in Japanese elderly using conditional logistic LASSO regression.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Comorbidity burden and fracture pattern as predictors of early postoperative medical complications following bipolar hemiarthroplasty for displaced femoral neck fractures: a retrospective cohort study.Archives of orthopaedic and trauma surgery · 2026Article
- Real-world evidence of the impact of polypharmacy on mortality and recovery after hip fracture in elderly patients.Scientific reports · 2026Observational
- Electromyographic Prediction of Walking Independence in Patients With Incomplete Spinal Cord Injury.Archives of rehabilitation research and clinical translation · 2025Article
- Emerging basic science concepts in geriatric fracture fixation and patient recovery.OTA international : the open access journal of orthopaedic trauma · 2025Article
- The impact of hip fracture anatomy on admission haemoglobin levels and perioperative transfusion requirements: a 32-year experience.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Observational
- Comparative analysis of geriatric hip fracture management outcomes in teaching and nonteaching hospitals in Jordan.Scientific reports · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the association between hip fracture and associated factors, including polypharmacy, and develop an optimal predictive model, we conducted a population-based matched case-control study using the health insurance claims data on hip fracture among Japanese patients. We included 34,717 hospitalized Japanese patients aged ≥ 65 years with hip fracture and 34,717 age- and sex- matched controls who were matched 1:1. This study included 69,434 participants. Overall, 16 variable comorbidities and 60 variable concomitant medications were used as explanatory variables. The participants were added to early elderly and late elderly categories for further analysis. The odds ratio of hip fracture increased with the number of medications only in the early elderly. AUC was highest for early elderly (AUC, 0.74, 95% CI 0.72-0.76). Use of anti-Parkinson's drugs had the largest coefficient and was the most influential variable in many categories. This study confirmed the association between risk factors, including polypharmacy and hip fracture. The risk of hip fracture increased with an increase in medication number taken by the early elderly and showed good predictive accuracy, whereas there was no such association in the late elderly. Therefore, the early elderly in Japan should be an active target population for hip fracture prevention.
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