Evidence map›Paper›PMID 37804401›Full record

ArticleCell biology and toxicology2023

Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway.

Lu Yang, Tingting Zhang, Penglu Wang, Wenting Chen, Wanmei Liu, Xiaoyu He, Yuxin Zhang, Shasha Jin, Zhijie Luo, Zunjian Zhang and 2 more

Abstract read
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In one paragraph

Article in Cell biology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lu Yang *New Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Tingting Zhang *New Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Penglu WangNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Wenting ChenNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Wanmei LiuNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Xiaoyu HeNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Yuxin ZhangNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Shasha JinNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Zhijie LuoNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China.
Zunjian ZhangNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China. zzj@cpu.edu.cn.
Xinzhi WangNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China. wangxz@cpu.edu.cn.
Jun LiuNew Drug Screening Center, China Pharmaceutical University, Nanjing, 210009, China. junliu@cpu.edu.cn.
National Center for Drug Screening · CNChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

V-domain immunoglobulin suppressor of T-cell activation (VISTA), an important negative checkpoint protein, participates in immunoregulation. Systemic lupus erythematosus (SLE) is an autoimmune disease in which patients exhibit high levels of autoantibodies and multi-organ tissue injury, primarily involving the kidney and skin. In wild-type (WT) mice and Vsir

Indexed as

Lupus Erythematosus, SystemicNF-kappa BAnimalsAutoantibodiesCytokinesDisease Models, AnimalHumansImatinib MesylateInterferonsLeukocytes, MononuclearMiceMice, Inbred MRL lprMolecular Docking SimulationTerpenesAutoantibodiesCytokinesImatinib MesylateInterferonsNF-kappa BpristaneTerpenesImatinibM351-0056noncanonical NF-κBSystemic lupus erythematosusType I interferonVISTA

Identifiers

PMID37804401
OpenAlexW4387429218

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.