Evidence map›Paper›PMID 37808709›Full record

ArticlebioRxiv : the preprint server for biology2023

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy.

Thomas N O'Connor, Nan Zhao, Haley M Orciuoli, Alice Brasile, Laura Pietrangelo, Miao He, Linda Groom, Jennifer Leigh, Zahra Mahamed, Chen Liang and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Thomas N O'ConnorDepartment of Biomedical Genetics, Genetics and Genomics Graduate Program, University of Rochester Medical Center, Rochester, NY, USA.
Nan ZhaoDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Haley M OrciuoliDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Alice BrasileCAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.
Laura PietrangeloCAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.
Miao HeDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Linda GroomDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Jennifer LeighDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Zahra MahamedDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Chen LiangDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Sundeep MalikDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Feliciano ProtasiCAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.
Robert T DirksenDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-3182-1755
University of Rochester Medical Center · USUniversity of Chieti-Pescara · IT

Funding

Characterization of the Exercise-induced Orai1 Proteome in Skeletal MuscleR21AR081068 · NIAMS · UNIVERSITY OF ROCHESTER · PI DIRKSEN, ROBERT T · 2022 to 2023
$373k
NIAMS NIH HHS R21 AR081068
6 · The paper itself

Abstract

Tubular aggregate myopathy (TAM) is an inherited skeletal muscle disease associated with progressive muscle weakness, cramps, and myalgia. Tubular aggregates (TAs) are regular arrays of highly ordered and densely packed SR straight-tubes in muscle biopsies; the extensive presence of TAs represent a key histopathological hallmark of this disease in TAM patients. TAM is caused by gain-of-function mutations in proteins that coordinate store-operated Ca

Indexed as

aggregateexercisemitochondriaMyopathyphysiologyproteomicssarcoplasmic reticulumskeletal muscle

Identifiers

PMID37808709
PMCPMC10557777
OpenAlexW4387221302

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.