Evidence map›Paper›PMID 37808750›Full record

ArticlebioRxiv : the preprint server for biology2023

Activation induces shift in nutrient utilization that differentially impacts cell functions in human neutrophils.

Emily C Britt, Xin Qing, James A Votava, Jorgo Lika, Andrew Wagner, Simone Shen, Nicholas L Arp, Hamidullah Khan, Stefan M Schieke, Christopher D Fletcher and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Emily C BrittMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-6177-139X
Xin QingMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-3579-706X
James A VotavaMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-1452-4468
Jorgo LikaMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0003-4563-7569
Andrew WagnerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-6777-4006
Simone ShenDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-1886-6481
Nicholas L ArpMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0001-8709-0667
Hamidullah KhanDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI, USA. Department of Dermatology, Georgetown University Medical Center and Washington DC VA Medical Center, Washington, D.C., USA.
Stefan M SchiekeDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI, USA. Department of Dermatology, Georgetown University Medical Center and Washington DC VA Medical Center, Washington, D.C., USA.ORCID 0000-0002-6762-0963
Christopher D FletcherUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Anna HuttenlocherCell and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-7940-6254
Jing FanMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-5326-5358

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Lu Mao · 1985 to 2026
$142.6M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
NRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4M
Cell migration and wound repairR35GM118027 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2016 to 2026
$7.5M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Metabolic rewiring coupled to the production of reactive oxygen and nitrogen species (RONS)R35GM147014 · NIGMS · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Jing Fan · 2022 to 2026
$2.1M
NCATS NIH HHS TL1 TR002375NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA014520NIGMS NIH HHS R35 GM118027NIGMS NIH HHS R35 GM147014NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Neutrophils - the first responders in innate immunity - perform a variety of effector functions associated with specific metabolic demand. To maintain fitness and support functions, neutrophils have been found to utilize extracellular glucose, intracellular glycogen, and other alternative substrates. However, the quantitative contribution of these nutrients under specific conditions and the relative dependence of various cell functions on specific nutrients remain unclear. Here, using

Identifiers

PMID37808750
PMCPMC10557599

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.