Evidence map›Paper›PMID 37809421›Full record

ArticleHeliyon2023

Breast cancer stem cells tolerate chromosomal instability during tumor progression via c-Jun/AXL stress signaling.

Shahnawaz A Baba, Qi Sun, Samson Mugisha, Shreyas Labhsetwar, Richard Klemke, Jay S Desgrosellier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Chromosomal instability as an architect of the cancer stemness landscape.Frontiers in cell and developmental biology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shahnawaz A BabaDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Qi SunDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Samson MugishaDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Shreyas LabhsetwarDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Richard KlemkeDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Jay S DesgrosellierDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromosomal instability (CIN) is critical for tumor evolution, yet its relationship with stemness is unclear. Here, we describe CIN as a key stress induced during tumor initiation that is uniquely tolerated by breast cancer stem cells in an activated signaling state (aCSCs). While we noted elevated CIN specifically in tumors from aCSCs, this was not intrinsic to these cells, as baseline levels were similar to non-stem cell types. This suggests that CIN is induced during tumor initiation, and that aCSCs can better tolerate this stress. Further, this increased CIN may be transient, as it was only in low-burden aCSC tumors, with levels diminishing in more established disease. Phospho-array profiling revealed specific activation of c-Jun stress signaling in aCSCs, which we hypothesized could induce genes responsible for CIN tolerance. Indeed, we identified

Indexed as

Breast cancerChromosomal missegregationStem cell activationStress toleranceTumor initiation

Identifiers

PMID37809421
PMCPMC10559946
OpenAlexW4386760732

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.