ArticleiScience2023
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
Open access · goldAbstract read
In one paragraph
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections.Communications biology · 2025Pooled it
- Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Proteomic analysis reveals divergent inflammatory mechanisms of COVID-associated Guillain-Barré syndrome.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Early Fc-effector antibody signatures impact COVID-19 disease trajectory.medRxiv : the preprint server for health sciences · 2026Article
- Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.Research square · 2025Article
- Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients.Cell reports. Medicine · 2025Article
- Integrated renin angiotensin system dysregulation and immune profiles predict COVID-19 disease severity in a South African cohort.Scientific reports · 2025Article
- Evaluation of inflammatory biomarkers and their association with anti-SARS-CoV-2 antibody titers in healthcare workers vaccinated with BNT162B2.Frontiers in immunology · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
56 authors at 4 institutions in 3 countries.
Jason A HackneyGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Haridha ShivramGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Jason Vander HeidenGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Chris OverallGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Luz OrozcoGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Xia GaoGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Eugene KimGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Nathan WestGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Aditi QamraHoffman-La Roche Limited, 7070 Mississauga Road, Mississauga, ON L5N 5M8, Canada.
Diana ChangGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Arindam ChakrabartiGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
David F ChoyGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Alexis J CombesUniversity of California San Francisco, San Francisco, CA, USA.
Tristan CourauUniversity of California San Francisco, San Francisco, CA, USA.
Gabriela K FragiadakisUniversity of California San Francisco, San Francisco, CA, USA.
Arjun Arkal RaoUniversity of California San Francisco, San Francisco, CA, USA.
Arja RayUniversity of California San Francisco, San Francisco, CA, USA.
Jessica TsuiUniversity of California San Francisco, San Francisco, CA, USA.
Kenneth HuUniversity of California San Francisco, San Francisco, CA, USA.
Nicholas F KuhnUniversity of California San Francisco, San Francisco, CA, USA.
Matthew F KrummelUniversity of California San Francisco, San Francisco, CA, USA.
David J ErleUniversity of California San Francisco, San Francisco, CA, USA.
Kirsten KangelarisUniversity of California San Francisco, San Francisco, CA, USA.
Aartik SarmaUniversity of California San Francisco, San Francisco, CA, USA.
Zoe LyonUniversity of California San Francisco, San Francisco, CA, USA.
Carolyn S CalfeeUniversity of California San Francisco, San Francisco, CA, USA.
Prescott G WoodruffUniversity of California San Francisco, San Francisco, CA, USA.
Rajani GhaleUniversity of California San Francisco, San Francisco, CA, USA.
Eran MickUniversity of California San Francisco, San Francisco, CA, USA.
Ashley ByrneUniversity of California San Francisco, San Francisco, CA, USA.
Beth Shoshana ZhaUniversity of California San Francisco, San Francisco, CA, USA.
Charles LangelierUniversity of California San Francisco, San Francisco, CA, USA.
Carolyn M HendricksonUniversity of California San Francisco, San Francisco, CA, USA.
Monique G P van der WijstDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
George C HartoularosUniversity of California San Francisco, San Francisco, CA, USA.
Tianna GrantUniversity of California San Francisco, San Francisco, CA, USA.
Raymund BuenoUniversity of California San Francisco, San Francisco, CA, USA.
David S LeeUniversity of California San Francisco, San Francisco, CA, USA.
John R GreenlandUniversity of California San Francisco, San Francisco, CA, USA.
Yang SunUniversity of California San Francisco, San Francisco, CA, USA.
Richard PerezUniversity of California San Francisco, San Francisco, CA, USA.
Anton OgorodnikovUniversity of California San Francisco, San Francisco, CA, USA.
Alyssa WardUniversity of California San Francisco, San Francisco, CA, USA.
Chun Jimmie YeUniversity of California San Francisco, San Francisco, CA, USA.
UCSF COMET Consortium
Thiru RamalingamGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Jacqueline M McBrideGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Fang CaiGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Anastasia TeterinaHoffman-La Roche Limited, 7070 Mississauga Road, Mississauga, ON L5N 5M8, Canada.
Min BaoGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Larry TsaiGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Ivan O RosasBaylor College of Medicine, 7200 Cambridge St, Houston, TX 77030, USA.
Aviv RegevGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Sharookh B KapadiaGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Rebecca N BauerGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Carrie M RosenbergerGenentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
University of California, San Francisco · USRoche (Canada) · CABaylor College of Medicine · USUniversity Medical Center Groningen · NL
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MMolecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4MRESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2MPrecision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8MThe Tumor Microenvironment Niche of Type I conventional Dendritic CellsR01CA197363 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2017 to 2026
$4.5MGenetic regulation and immunological function of ERAP2 haplotypesR01AI136972 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, CHUN JIMMIE · 2018 to 2022
$3.5MCONTROL OF T CELL SYNAPSE STABILIZATION AND SIGNALINGR37AI052116 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2023 to 2026
$2.5MFine mapping rheumatic disease variants using functional genomic sequencingR01AR071522 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, CHUN JIMMIE · 2017 to 2020
$1.5MAcute Respiratory Distress Syndrome after Isolated Traumatic Brain Injury: Platelet Biology, Endothelial Activation, and Mechanical VentilationK23HL133495 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDRICKSON, CAROLYN MARIE · 2016 to 2020
$994kImpact of gut bacterial metabolites on lung function and diseaseK08HL165106 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Vaibhav Upadhyay · 2023 to 2026
$676kFine mapping rheumatic disease variants using functional genomic sequencingU01HG012192 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YE, CHUN JIMMIE · 2021 to 2021
$526kNCI NIH HHS R01 CA197363NCI NIH HHS T32 CA108462NHGRI NIH HHS U01 HG012192NHLBI NIH HHS K08 HL165106NHLBI NIH HHS K23 HL133495NHLBI NIH HHS R35 HL140026NIAID NIH HHS R01 AI136972NIAID NIH HHS R37 AI052116NIAID NIH HHS U19 AI077439NIAMS NIH HHS P30 AR070155NIAMS NIH HHS R01 AR071522
Abstract
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across 7 cohorts. This program was associated with greater clinical severity and predicted future mechanical ventilation and death. EN-RAGE
Indexed as
Clinical geneticsImmune responseMolecular medicine
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.