Evidence map›Paper›PMID 37811523›Full record

ArticleCerebral circulation - cognition and behavior2023

Testing the cognitive effects of tadalafil. Neuropsychological secondary outcomes from the PASTIS trial.

Mathilde Mh Pauls, Jessica Fish, Lauren R Binnie, Philip Benjamin, Shai Betteridge, Brian Clarke, Mohani-Preet K Dhillon, Rita Ghatala, Fearghal Ah Hainsworth, Franklyn A Howe and 15 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00123456, which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00123456 no registry record found
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 7 countries.

Mathilde Mh PaulsMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Jessica FishNeuropsychology, St George's University Hospitals NHS Foundation Trust, London, UK.
Lauren R BinnieMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Philip BenjaminMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Shai BetteridgeNeuropsychology, St George's University Hospitals NHS Foundation Trust, London, UK.
Brian ClarkeDepartment of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.
Mohani-Preet K DhillonMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Rita GhatalaSouth London Stroke Research Network, London, UK.
Fearghal Ah HainsworthMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Franklyn A HoweMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Usman KhanDepartment of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.
Christina KruuseDepartment of Neurology and Neurovascular Research Unit, Herlev Gentofte Hospital, Denmark.
Jeremy B MadiganNeuroradiology, St George's University Hospitals NHS Foundation Trust, London, UK.
Barry MoynihanDepartment of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.
Bhavini PatelDepartment of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.
Anthony C PereiraMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Egill RostrupMental Health Centre, University of Copenhagen, Glostrup, Denmark.
Anan By ShtayaMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Catherine A SpillingMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Sarah TrippierSouth London Stroke Research Network, London, UK.
Rebecca WilliamsSouth London Stroke Research Network, London, UK.
Robin YoungRobertson Centre for Biostatistics, University of Glasgow, UK.
Thomas R BarrickMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Jeremy D IsaacsMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
Atticus H HainsworthMolecular & Clinical Sciences Research Institute, St George's University of London, UK.
St George's, University of London · GBSt George’s University Hospitals NHS Foundation Trust · GBUniversity of Glasgow · GBBeaumont Hospital · IEGentofte Hospital · DKUniversity of Copenhagen · DK

Funding

Medical Research Council MR/T033371/1
6 · The paper itself

Abstract

Cerebral small vessel disease (SVD) is a major cause of cognitive impairment in older people. As secondary endpoints in a phase-2 randomised clinical trial, we tested the effects of single administration of a widely-used PDE5 inhibitor, tadalafil, on cognitive performance in older people with SVD. In a double-blinded, placebo-controlled, cross-over trial, participants received tadalafil (20 mg) and placebo on two visits ≥ 7 days apart (randomised to order of treatment). The Montreal Cognitive Assessment (MOCA) was administered at baseline, alongside a measure to estimate optimal intellectual ability (Test of Premorbid Function). Then, before and after treatment, a battery of neuropsychological tests was administered, assessing aspects of attention, information processing speed, working memory and executive function. Sixty-five participants were recruited and 55 completed the protocol ( Clinical trial registration: http://www.clinicaltrials.gov. Unique identifier: NCT00123456, https://eudract.ema.europa.eu. Unique identifier: 2015-001,235-20NCT00123456.

Indexed as

Clinical trialsCognitive testingPde5Small vessel diseaseTadalafilVascular cognitive impairmentVascular dementia

Identifiers

PMID37811523
PMCPMC10550803
OpenAlexW4387063683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.