Evidence map›Paper›PMID 37814028›Full record

ReviewAmino acids2023

Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism.

Xiao-Yue Li, Zi-Xin Zeng, Zhi-Xing Cheng, Yi-Lin Wang, Liang-Jun Yuan, Zhi-Yong Zhai, Wei Gong

Open access · hybridAbstract readReview
In one paragraph

Review in Amino acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Arginine utilization inInfection and immunity · 2025
    Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiao-Yue LiThe First School of Clinical Medicine, Southern Medical University, Guangdong, 510515, China.
Zi-Xin ZengThe First School of Clinical Medicine, Southern Medical University, Guangdong, 510515, China.
Zhi-Xing ChengThe First School of Clinical Medicine, Southern Medical University, Guangdong, 510515, China.
Yi-Lin WangThe First School of Clinical Medicine, Southern Medical University, Guangdong, 510515, China.
Liang-Jun YuanThe First School of Clinical Medicine, Southern Medical University, Guangdong, 510515, China.
Zhi-Yong ZhaiShenzhen Hospital, Southern Medical University, Shenzhen Clinical Medical College, Southern Medical University, Guangdong, 518101, China. drzzy0930@outlook.com.
Wei GongShenzhen Hospital, Southern Medical University, Shenzhen Clinical Medical College, Southern Medical University, Guangdong, 518101, China. gongwei@smu.edu.cn.
Southern Medical University · CNSouthern Medical University Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apart from cancer, metabolic reprogramming is also prevalent in other diseases, such as bacterial infections. Bacterial infections can affect a variety of cells, tissues, organs, and bodies, leading to a series of clinical diseases. Common Pathogenic bacteria include Helicobacter pylori, Salmonella enterica, Mycobacterium tuberculosis, Staphylococcus aureus, and so on. Amino acids are important and essential nutrients in bacterial physiology and support not only their proliferation but also their evasion of host immune defenses. Many pathogenic bacteria or opportunistic pathogens infect the host and lead to significant changes in metabolites, especially the proteinogenic amino acids, to inhibit the host's immune mechanism to achieve its immune evasion and pathogenicity. Here, we review the regulation of host metabolism, while host cells are infected by some common pathogenic bacteria, and discuss how amino acids of metabolic reprogramming affect bacterial infections, revealing the potential adjunctive application of amino acids alongside antibiotics.

Indexed as

Bacterial InfectionsMycobacterium tuberculosisAmino AcidsAnti-Bacterial AgentsHumansAmino AcidsAnti-Bacterial AgentsAmino acidsBacterial infectionsMetabolic reprogrammingNutrition

Identifiers

PMID37814028
PMCPMC10689525
OpenAlexW4387449060

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.