Evidence mapPaperPMID 37814270Full record

ReviewMolecular cancer2023

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation.

Mohammad Chehelgerdi, Matin Chehelgerdi, Omer Qutaiba B Allela, Renzon Daniel Cosme Pecho, Narayanan Jayasankar, Devendra Pratap Rao, Tamilanban Thamaraikani, Manimaran Vasanthan, Patrik Viktor, Natrayan Lakshmaiya and 7 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecular cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 364 papers.

0numbers the graph read from it
0cells of the map it votes in
364citing papers in PubMed
138.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

364 citing papers in PubMed, 902 citations in OpenAlex.

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304 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 10 countries.

Mohammad ChehelgerdiNovin Genome (NG) Institute, Research and Development Center for Biotechnology, Shahrekord, Chaharmahal and Bakhtiari, Iran. Chehelgerdi1992@gmail.com.ORCID http://orcid.org/0000-0002-3483-9424
Matin ChehelgerdiNovin Genome (NG) Institute, Research and Development Center for Biotechnology, Shahrekord, Chaharmahal and Bakhtiari, Iran.
Omer Qutaiba B AllelaDepartment of Pharmacy, Al-Noor University College, Nineveh, Iraq.
Renzon Daniel Cosme PechoDepartment of Biochemistry, Universidad San Ignacio de Loyola (USIL), Lima, Peru.
Narayanan JayasankarDepartment of Pharmacology, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, Kattankulathur, Tamil Nadu, 603203, India.
Devendra Pratap RaoDepartment of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur-208001, U.P, India.
Tamilanban ThamaraikaniDepartment of Pharmacology, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, Kattankulathur, Tamil Nadu, 603203, India.
Manimaran VasanthanDepartment of Pharmaceutics, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, Kattankulathur, Tamil Nadu, 603203, India.
Patrik ViktorKeleti Károly Faculty of Business and Management, Óbuda University, Tavaszmező U. 15-17, 1084, Budapest, Hungary.
Natrayan LakshmaiyaDepartment of Mechanical Engineering, Saveetha School of Engineering, SIMATS, Chennai, Tamil Nadu, India.
Mohamed J SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Ayesha AmajdFaculty of Organization and Management, Silesian University of Technology, 44-100, Gliwice, Poland.
Mabrouk A Abo-ZaidDepartment of Biology, College of Science, Jazan University, 82817, Jazan, Saudi Arabia.
Roxana Yolanda Castillo-AcoboUniversidad Nacional de San Agustin de Arequipa, Arequipa, Peru.
Ahmed H IsmailDepartment of Biology, College of Science, Jazan University, 82817, Jazan, Saudi Arabia.
Ali H AminDeanship of Scientific Research, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.
Reza Akhavan-SigariDepartment of Neurosurgery, University Medical Center, Tuebingen, Germany.
SRM Institute of Science and Technology · INJazan University · SAShahrekord University · IRAl-Nisour University College · IQMiddle East University · JOObuda University · HUSaveetha University · INSilesian University of Technology · PLUmm al-Qura University · SAUniversidad Nacional de San Agustin de Arequipa · PEUniversidad San Ignacio de Loyola · PEWarsaw Management University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells. In this review, we analyze some of the authorized formulations and discuss the challenges of translating findings from the lab to the clinic. This study highlights the various nanocarriers and compounds that can be used for selective tumor targeting and the inherent difficulties in cancer therapy. Nanotechnology provides a promising platform for improving cancer detection and treatment in the future, but further research is needed to overcome the current limitations in clinical translation.

Indexed as

NanoparticlesNeoplasmsDrug CarriersDrug CompoundingDrug Delivery SystemsHumansNanotechnologyDrug CarriersCancer detectionCancer treatmentHuman trialsMaterials scienceMedicinal purposesNanocarriersNanoscale targeting techniquesNanotechnologyProtein engineering

Identifiers

PMID37814270
PMCPMC10561438
OpenAlexW4387452756

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.