Evidence map›Paper›PMID 37814874›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Near-infrared light therapy ameliorates depression-induced intestinal dysfunction in rats possibly by activating PGC-1

Y Zheng, Y Hou, F Li, X Shi, Y Tao, X Zhao, H Hu, L Yang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Y ZhengHealth Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Y HouHealth Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
F LiBasic Medicine Experimental Teaching Center, Xi'an Jiaotong University, Xi'an 710061, China.
X ShiHealth Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Y TaoHealth Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
X ZhaoHealth Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
H HuBasic Medicine Experimental Teaching Center, Xi'an Jiaotong University, Xi'an 710061, China.
L YangDepartment of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Xi'an Jiaotong University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of near-infrared (NIR) light therapy on depression-induced intestinal dysfunction in rats and explore the possible mechanism.

methodsThirty-two male SD rats were randomly divided into control group, model group, low-dose NIR light group and high-dose NIR light group. All the rats except for those in the control group were subjected to chronic restrained stress (CRS) for 4 weeks, and NIR light therapy of the head was administered in the two NIR light groups. The depression- like behaviors, intestinal functions, fecal water content and number of fecal pellets of the rats were evaluated. HE staining was used for detecting histopathological changes in the hippocampus and colon, and hippocampal expressions of BDNF, Nrf2 and PGC-1

resultsThe rats in the CRS model group showed significantly increased immobility time and visceral sensitivity in the behavioral tests, decreased fecal pellets and fecal water content, and lowered expressions of BDNF, Nrf2, and PGC-1

conclusionNIR light therapy can significantly improve depression-like behavior and intestinal function in rats possibly by ameliorating oxidative stress

Indexed as

Brain-Derived Neurotrophic FactorDepressionAnimalsHippocampusMaleNF-E2-Related Factor 2PhototherapyRatsRats, Sprague-DawleySignal TransductionWaterBrain-Derived Neurotrophic FactorNF-E2-Related Factor 2Waterbrain-derived neurotrophic factordepression-like behaviorgastrointestinal dysfunctionnear-infrared light

Identifiers

PMID37814874
PMCPMC10563092
OpenAlexW4387473385

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.