Evidence map›Paper›PMID 37815519›Full record

ArticleMicrobiology (Reading, England)2023

Mutational hotspots lead to robust but suboptimal adaptive outcomes in certain environments.

Louise M Flanagan, James S Horton, Tiffany B Taylor

Abstract read
In one paragraph

Article in Microbiology (Reading, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Louise M FlanaganDepartment of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
James S HortonDepartment of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
Tiffany B TaylorDepartment of Life Sciences, University of Bath, Bath, BA2 7AY, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/T012994/1
6 · The paper itself

Abstract

The observed mutational spectrum of adaptive outcomes can be constrained by many factors. For example, mutational biases can narrow the observed spectrum by increasing the rate of mutation at isolated sites in the genome. In contrast, complex environments can shift the observed spectrum by defining fitness consequences of mutational routes. We investigate the impact of different nutrient environments on the evolution of motility in

Indexed as

MutationPhenotypeconstrained evolutionevolutionary rescuemutational biasnutrient environmentpredicting evolutionPseudomonas fluorescens

Identifiers

PMID37815519
PMCPMC10634368

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.