Statins × lipids

SynthesisCardiovascular drugs and therapy2025

Effect of Intensive Lipid-Lowering Therapy on Coronary Plaque Stabilization Derived from Optical Coherence Tomography: a Meta-analysis and Meta-regression.

Sen Liu et al.PubMed ↗Publisher ↗

  • High-intensity statin therapycuts both waysHigher minimum FCT, lower maximum lipid arc.Randomised, small.
  • Combinative approach including PCSK9 antibodies and statinsno clear effectHigher minimum FCT.Nothing cleared the noise.
  • Combined application of PCSK9 antibodies and statinsno clear effectLower maximum lipid arc.Nothing cleared the noise.

What the trial testedrandomised · 972 people · 2025

Randomised comparison

Probably raised minimum FCT

+1.03+0.67 to +1.39

high-intensity statin therapy

As reported

difference 1.03, 95% CI 0.67–1.39

Randomised comparison

Probably lowered maximum lipid arc

−0.42−0.65 to −0.19

high-intensity statin therapy

As reported

difference −0.42, 95% CI −0.65 to −0.19

Not counted

Probably raised minimum FCT

+1.17+0.62 to +1.73

combinative approach including PCSK9 antibodies and statins

As reported

difference 1.17, 95% CI 0.62–1.73

Not counted

Probably lowered maximum lipid arc

−0.98−1.26 to −0.70

combined application of PCSK9 antibodies and statins

As reported

difference −0.98, 95% CI −1.26 to −0.70

Who was studied, and how

972people with dyslipidemia, in this paper

The trial randomly assignedassigned by chance

high-intensity statin therapy
the rest

Probably raised minimum FCT+1.03

Probably lowered maximum lipid arc−0.42

randomised

The trial randomly assignedassigned by chance

combinative approach including PCSK9 antibodies and statins
the rest

Probably raised minimum FCT+1.17

randomised

the abstract, start to end

(5 studies with 204 participants; SMD, 1.03; 95% CI, 0.67 to 1.39; P < 0.01), as well as a combinative approach including PCSK9 antibodies and statins (3 studies with 522 participants; SMD, 1.17; 95% CI, 0.62 to 1.73; P <

(4 studies with 183 participants; SMD, -0.42; 95% CI, -0.65 to -0.19; P < 0.01) or the combined application of PCSK9 antibodies and statins (2 studies with 222 participants; SMD, -0.98; 95% CI, -1.26 to -0.70; P <

← favours treatmentfavours comparator →
could be chance
Minimum FCThigh-intensity statin therapy
1.030.67–1.39
Minimum FCTcombinative approach including PCSK9 antibodies and statins
1.170.62–1.73
Maximum lipid archigh-intensity statin therapy
−0.42−0.65 to −0.19
Maximum lipid arccombined application of PCSK9 antibodies and statins
−0.98−1.26 to −0.70
StatinsPCSK9 inhibitorsLipidsAdverse events & safety
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5 papers cite it

2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 37815648