Evidence map›Paper›PMID 37817932›Full record

ArticleiScience2023

Feeding neurons integrate metabolic and reproductive states in mice.

Megan G Massa, Rachel L Scott, Alexandra L Cara, Laura R Cortes, Paul B Vander, Norma P Sandoval, Jae W Park, Sahara L Ali, Leandro M Velez, Huei-Bin Wang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Megan G MassaDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Rachel L ScottDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Alexandra L CaraDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Laura R CortesDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Paul B VanderDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Norma P SandovalDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Jae W ParkDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Sahara L AliDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Leandro M VelezDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Huei-Bin WangDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Shomik S AtiDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Bethlehem TesfayeDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Karen ReueDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
J Edward van VeenDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Marcus M SeldinDepartment of Biological Chemistry, School of Medicine, University of California - Irvine, Irvine, CA 92697, USA.
Stephanie M CorreaDepartment of Integrative Biology and Physiology, University of California - Los Angeles, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUniversity of California, Irvine · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
Sex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6M
The impact of estrogen receptor alpha on cardiomyocellular metabolism and healthU54HL170326 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hooman Allayee · 2023 to 2026
$7.5M
Integrative approaches to dissection of endocrine communicationDP1DK130640 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SELDIN, MARCUS MICHAEL · 2021 to 2025
$3.2M
Estrogenic modulation of neural circuits that control temperatureR01AG066821 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORREA, STEPHANIE · 2020 to 2024
$2.1M
Hypothalamic gating of the anorexic effects of estradiolR01DK136073 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Stephanie Correa · 2023 to 2026
$2.0M
NCATS NIH HHS UL1 TR001881NHLBI NIH HHS U54 HL170326NIA NIH HHS R01 AG066821NIDDK NIH HHS DP1 DK130640NIDDK NIH HHS R01 DK136073NIDDK NIH HHS U54 DK120342NIGMS NIH HHS R25 GM055052
6 · The paper itself

Abstract

Balance between metabolic and reproductive processes is important for survival, particularly in mammals that gestate their young. How the nervous system coordinates this balance is an active area of study. Herein, we demonstrate that somatostatin (SST) neurons of the tuberal hypothalamus alter feeding in a manner sensitive to metabolic and reproductive states in mice. Whereas chemogenetic activation of SST neurons increased food intake across sexes, ablation decreased food intake only in female mice during proestrus. This ablation effect was only apparent in animals with low body mass. Fat transplantation and bioinformatics analysis of SST neuronal transcriptomes revealed white adipose as a key modulator of these effects. These studies indicate that SST hypothalamic neurons integrate metabolic and reproductive cues by responding to varying levels of circulating estrogens to modulate feeding differentially based on energy stores. Thus, gonadal steroid modulation of neuronal circuits can be context dependent and gated by metabolic status.

Indexed as

Cellular neuroscienceNeurosciencePhysiology

Identifiers

PMID37817932
PMCPMC10561062
OpenAlexW4386696885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.