ArticleClinical, cosmetic and investigational dermatology2023
Hyaluronic Acid Fillers and ASIA Syndrome: Case Studies.
Article in Clinical, cosmetic and investigational dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Exploring the Immunological Implications of Insoluble Particulate Impurities in Hyaluronic Acid Fillers: Integrated Physicochemical and Histological Analyses of the Cohesive Polydensified Matrix Range.Clinical, cosmetic and investigational dermatology · 2026Article
- Incidence and Characteristics of Delayed Inflammatory Reactions Secondary to Hyaluronic Acid Filler Injections: A Systematic Review With Meta-Analysis.Aesthetic surgery journal. Open forum · 2026Review
- Dermal Filler Use in Patients Undergoing Chemotherapy and Radiation Therapy.JMIR dermatology · 2025Review
- Management of Hyaluronic Acid Filler-Induced Refractory Sterile Abscess With Modified Munhoz-Cavallieri Lavage Protocol: A Case Series.Journal of cosmetic dermatology · 2025Article
- Recent regulatory developments in EU Medical Device Regulation and their impact on biomaterials translation.Bioengineering & translational medicine · 2025Review
- Symptoms of ASIA Syndrome in a Female Patient with Tattoos - A Case Report.Clinical, cosmetic and investigational dermatology · 2025Article
- Systemic Lupus Erythematosus (SLE) Induced by ASIA Syndrome After the Aesthetic Medicine Procedures-A Case Report.Journal of clinical medicine · 2024Article
- Adverse effects of the aesthetic use of botulinum toxin and dermal fillers on the face: a narrative review.Anais brasileiros de dermatologiaReview
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A continuous increase in the popularity of esthetic procedures with the use of substances as HA has been observed for many years, which might be contributing to an increase in the number of adverse events. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) can be provoked by hyaluronic acid (HA), which belongs to substances meeting the criteria of adjuvants. Mechanisms of the innate and acquired immune response are activated, leading to the dysregulation of T and B lymphocytes, inability to recognize one's own antigens, inflammation, damage to one's own tissues, and ultimately to autoimmunity. The objective of this article is to present a case-series study of patients who developed ASIA syndrome following HA injection after delayed inflammatory reaction (DIR) and emphasize the importance of the need for long-term monitoring after such the reaction. Lack of knowledge about ASIA can lead to delayed diagnosis and serious consequences for the patients. People with a history of immunization reactions, severe allergic reactions, individual predisposition to autoimmunity or family predisposition to autoimmunity and previous exposure to adjuvants require special attention and long-term follow-up. This applies primarily to cases of DIR after the using of bioimplants, especially with treatment resistance, as in our reported cases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.