Evidence map›Paper›PMID 37819487›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Differentiating progressive supranuclear palsy from other movement disorders using transcranial sonography: a systematic review and meta-analysis.

Yafei Wen, Hui Zhou, Mengwen Xia, Qianqian Liu, Hongzhi Quan, Liangjuan Fang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Asymmetry in Atypical Parkinsonian Syndromes-A Review.Journal of clinical medicine · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yafei WenDepartment of Ultrasound, the Third Xiangya Hospital of Central South University, Changsha, China.
Hui ZhouDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, China.
Mengwen XiaDepartment of Ultrasound, the Third Xiangya Hospital of Central South University, Changsha, China.
Qianqian LiuDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, China.
Hongzhi QuanDepartment of Oral Maxillofacial Surgery, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, China.
Liangjuan FangDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, China. fangliangjuan@csu.edu.cn.ORCID http://orcid.org/0000-0001-5346-6515

Funding

Hunan Province Natural Science Foundation 2020JJ4457the National Natural Science Foundation of China No.81501110
6 · The paper itself

Abstract

Progressive supranuclear palsy (PSP) is an atypical parkinsonism that presents with different phenotypes. There are still no validated diagnostic biomarkers for early diagnosis of PSP. Transcranial sonography (TCS) is a promising tool in the differential diagnosis of parkinsonian disorders; however, there are no systematic investigations about the application of TCS in PSP patients. Therefore, we performed a systematic review and meta-analysis to discuss the role of TCS in diagnosing PSP by systematically searching PubMed, Cochrane Library, Chinese National Knowledge Infrastructure and Wan Fang databases. Of 66 obtained records, 16 articles, including 366 patients with PSP, were included. Our results showed the estimated random-effects pooled prevalence of substantia nigra hyperechogenicity in patients with PSP was 22% (95% CI 12-32%), lenticular nucleus hyperechogenicity was 70% (95% CI 52-82%), and enlarged third ventricle was 71% (95% CI 55-85%). Additionally, a normal echogenicity substantia nigra in TCS showed 70% sensitivity (95% CI 56-81%) and 86% specificity (95% CI 75-86%) to differentiate PSP from Parkinson's disease. In conclusion, TCS is an important supplementary biomarker for diagnosing PSP. At the same time, the diagnostic value of TCS in discriminating PSP from other atypical parkinsonism and between different PSP phenotypes needs further exploration.

Indexed as

Parkinson DiseaseParkinsonian DisordersSupranuclear Palsy, ProgressiveDiagnosis, DifferentialHumansUltrasonographyUltrasonography, Doppler, TranscranialLenticular nucleusParkinsonian disordersProgressive supranuclear palsySubstantia nigraTranscranial sonography

Identifiers

PMID37819487

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.