Evidence map›Paper›PMID 37822280›Full record

ArticleInternational journal of stem cells2024

Nervonic Acid Inhibits Replicative Senescence of Human Wharton's Jelly-Derived Mesenchymal Stem Cells.

Sun Jeong Kim, Soojin Kwon, Soobeen Chung, Eun Joo Lee, Sang Eon Park, Suk-Joo Choi, Soo-Young Oh, Gyu Ha Ryu, Hong Bae Jeon, Jong Wook Chang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sun Jeong KimCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0003-2344-4176
Soojin KwonCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0009-0006-1522-7584
Soobeen ChungCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0009-0008-3464-891X
Eun Joo LeeCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0009-0003-7371-2121
Sang Eon ParkCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0003-3315-6426
Suk-Joo ChoiDepartment of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8946-4789
Soo-Young OhDepartment of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-3002-0048
Gyu Ha RyuDepartment of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Korea.ORCID https://orcid.org/0000-0001-9240-1837
Hong Bae JeonCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0003-4420-9968
Jong Wook ChangCell and Gene Therapy Institute, ENCell Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0001-9335-5510
Samsung Medical Center · KRCell Biotech (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence causes cell cycle arrest and promotes permanent cessation of proliferation. Since the senescence of mesenchymal stem cells (MSCs) reduces proliferation and multipotency and increases immunogenicity, aged MSCs are not suitable for cell therapy. Therefore, it is important to inhibit cellular senescence in MSCs. It has recently been reported that metabolites can control aging diseases. Therefore, we aimed to identify novel metabolites that regulate the replicative senescence in MSCs. Using a fecal metabolites library, we identified nervonic acid (NA) as a candidate metabolite for replicative senescence regulation. In replicative senescent MSCs, NA reduced senescence-associated

Indexed as

Mesenchymal stem cellsMetabolitesNervonic acidReplicative senescence

Identifiers

PMID37822280
PMCPMC10899888
OpenAlexW4387563315

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.