Evidence map›Paper›PMID 37822747›Full record

ArticleFrontiers in microbiology2023

Activation of multiple stress responses in

Amanda Holstad Singleton, Olaug Elisabeth Torheim Bergum, Caroline Krogh Søgaard, Lisa Marie Røst, Cecilie Elisabeth Olsen, Fredrik Heen Blindheim, Synnøve Brandt Ræder, Frithjof A Bjørnstad, Eirik Sundby, Bård Helge Hoff and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Amanda Holstad SingletonDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Olaug Elisabeth Torheim BergumDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Caroline Krogh SøgaardDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Lisa Marie RøstDepartment of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Cecilie Elisabeth OlsenDepartment of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Fredrik Heen BlindheimDepartment of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Synnøve Brandt RæderDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Frithjof A BjørnstadDepartment of Materials Science and Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Eirik SundbyDepartment of Materials Science and Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Bård Helge HoffDepartment of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Per BruheimDepartment of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Marit OtterleiDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Norwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug combinations that reduce resistance development. The novel β-clamp targeting antimicrobial peptide BTP-001 was recently shown to have a strong additive effect in combination with the halogenated pyrrolopyrimidine JK-274. In this study, the molecular basis for this effect was examined by a comprehensive proteomic and metabolomic study of the individual and combined effects on

Indexed as

antimicrobial peptideAPIMmetabolomicsproteomicspyrrolopyrimidineStaphylococcus aureusstress response

Identifiers

PMID37822747
PMCPMC10564113
OpenAlexW4387057490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.