Evidence map›Paper›PMID 37823874›Full record

ArticleeLife2023

Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes.

Michele Brischigliaro, Alfredo Cabrera-Orefice, Susanne Arnold, Carlo Viscomi, Massimo Zeviani, Erika Fernández-Vizarra

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Rethinking Human Energy Metabolism.Current issues in molecular biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Formation of ICell metabolism · 2025
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 5 countries.

Michele BrischigliaroDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0003-1520-1342
Alfredo Cabrera-OreficeRadboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-2042-3794
Susanne ArnoldRadboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Carlo ViscomiDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Massimo ZevianiDepartment of Neurosciences, University of Padova, Padova, Italy.
Erika Fernández-VizarraDepartment of Biomedical Sciences, University of Padova, Padova, Italy.ORCID 0000-0002-2469-142X
University of Padua · IT

Funding

Telethon GGP19007Telethon GGP20013Telethon GJC21014
6 · The paper itself

Abstract

Mammalian mitochondrial respiratory chain (MRC) complexes are able to associate into quaternary structures named supercomplexes (SCs), which normally coexist with non-bound individual complexes. The functional significance of SCs has not been fully clarified and the debate has been centered on whether or not they confer catalytic advantages compared with the non-bound individual complexes. Mitochondrial respiratory chain organization does not seem to be conserved in all organisms. In fact, and differently from mammalian species, mitochondria from

Indexed as

Drosophila melanogasterMitochondrial MembranesAnimalsElectron TransportMammalsMitochondriaOxidative Phosphorylationbiochemistrychemical biologyD. melanogasterDrosophilaMitochondriaOXPHOSsupercomplexes

Identifiers

PMID37823874
PMCPMC10569793
OpenAlexW4379880596

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.