Evidence map›Paper›PMID 37824615›Full record

ArticleScience advances2023

A marmoset brain cell census reveals regional specialization of cellular identities.

Fenna M Krienen, Kirsten M Levandowski, Heather Zaniewski, Ricardo C H Del Rosario, Margaret E Schroeder, Melissa Goldman, Martin Wienisch, Alyssa Lutservitz, Victoria F Beja-Glasser, Cindy Chen and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 60 citations in OpenAlex.

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  10. A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 6 institutions in 2 countries.

Fenna M KrienenDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1400-6820
Kirsten M LevandowskiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-4811-9217
Heather ZaniewskiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-0239-9353
Ricardo C H Del RosarioDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Margaret E SchroederStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-2228-7482
Melissa GoldmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Martin WienischStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-5599-8205
Alyssa LutservitzDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Victoria F Beja-GlasserStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Cindy ChenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-3785-4168
Qiangge ZhangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-7297-0717
Ken Y ChanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Katelyn X LiMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0001-8799-0534
Jitendra SharmaMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Dana McCormackStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0008-6330-0314
Tay Won ShinMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0002-0061-522X
Andrew HarrahillMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0002-3133-6493
Eric NyaseMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Gagandeep MudharPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Abigail MauermannMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Alec WysokerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
James NemeshStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Seva KashinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Josselyn VergaraStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-3563-0577
Gabriele CheliniCenter for Mind/Brain Sciences, University of Trento, Piazza della Manifattura n.1, Rovereto (TN) 38068, Italy.ORCID 0000-0001-6654-4332
Jordane DimidschsteinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sabina BerrettaBasic Neuroscience Division, McLean Hospital, Belmont, MA 02478, USA.ORCID 0000-0002-4057-7766
Benjamin E DevermanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-6223-9303
Ed BoydenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0002-0419-3351
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6954-8184
Guoping FengStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Broad Institute · USMcGovern Institute for Brain Research · USHoward Hughes Medical Institute · USHarvard University · USPrinceton University · USUniversity of Trento · IT

Funding

A Molecular and Cellular Atlas of the Marmoset BrainU01MH114819 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING · 2017 to 2021
$6.9M
Novel AAVs Engineered for Efficient and Noninvasive Cross-Species Gene Editing Throughout the Central Nervous SystemUH3NS111689 · NINDS · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2021 to 2022
$2.7M
Novel AAVs engineered for efficient and noninvasive cross-species gene editing throughout the central nervous systemUG3NS111689 · NINDS · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2018 to 2020
$2.5M
A multi-modal, brain-wide atlas of astrocyte diversity across developmental stages and model speciesF31MH133329 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SCHROEDER, MARGARET ELIZABETH · 2023 to 2024
$97k
NIMH NIH HHS F31 MH133329NIMH NIH HHS U01 MH114819NINDS NIH HHS UG3 NS111689NINDS NIH HHS UH3 NS111689
6 · The paper itself

Abstract

The mammalian brain is composed of many brain structures, each with its own ontogenetic and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 million brain cells across 18 locations in the common marmoset, a New World monkey primed for genetic engineering, and examined gene expression patterns of cell types within and across brain structures. The adult transcriptomic identity of most neuronal types is shaped more by developmental origin than by neurotransmitter signaling repertoire. Quantitative mapping of GABAergic types with single-molecule FISH (smFISH) reveals that interneurons in the striatum and neocortex follow distinct spatial principles, and that lateral prefrontal and other higher-order cortical association areas are distinguished by high proportions of

Indexed as

CallithrixNeocortexAnimalsNeuronsTissue Distribution

Identifiers

PMID37824615
PMCPMC10569717
OpenAlexW4387568767

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.