Evidence map›Paper›PMID 37827362›Full record

ArticleDevelopmental biology2024

Loss of Baz1b in mice causes perinatal lethality, growth failure, and variable multi-system outcomes.

Christopher Pai, Basil A McIntosh, Russell H Knutsen, Mark D Levin, Kit Man Tsang, Beth A Kozel, Robert O Heuckeroth

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher PaiThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA, 19104; The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, 19104.
Basil A McIntoshNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, 20892.
Russell H KnutsenNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, 20892.
Mark D LevinNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, 20892.
Kit Man TsangNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, 20892.
Beth A KozelNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, 20892. Electronic address: beth.kozel@nih.gov.
Robert O HeuckerothThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA, 19104; The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, 19104. Electronic address: heuckerothr@chop.edu.
National Institutes of Health · USChildren's Hospital of Philadelphia · US

Funding

Modifiers of elastin arteriopathyZIAHL006212 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2016 to 2024
$9.7M
Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL006212
6 · The paper itself

Abstract

BAZ1B is one of 25-27 coding genes deleted in canonical Williams syndrome, a multi-system disorder causing slow growth, vascular stenosis, and gastrointestinal complaints, including constipation. BAZ1B is involved in (among other processes) chromatin organization, DNA damage repair, and mitosis, suggesting reduced BAZ1B may contribute to Williams syndrome symptoms. In mice, loss of Baz1b causes early neonatal death. 89.6% of Baz1b

Indexed as

Ductus Arteriosus, PatentWilliams SyndromeAnimalsBromodomain Containing ProteinsColonDNA RepairMiceNeuronsTranscription FactorsBaz1b protein, mouseBromodomain Containing ProteinsTranscription FactorsBAZ1BSurvivalSymptom variabilityWilliams syndrome

Identifiers

PMID37827362
PMCPMC10872721
OpenAlexW4387519160

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.