Evidence map›Paper›PMID 37827696›Full record

ArticleAging2023

LncRNA LINC00667 gets involved in clear cell renal cell carcinoma development and chemoresistance by regulating the miR-143-3p/ZEB1 axis.

Jianjun Zhao, Pengjie Chen, Chao Tan, Xiaolong Cheng, Weichuan Zhang, Chong Shen, Dongli Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jianjun ZhaoDepartment of Urology, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China.
Pengjie ChenDepartment of Geriatrics, Handan Central Hospital, Handan 056001, Hebei, China.
Chao TanDepartment of Urology, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China.
Xiaolong ChengDepartment of Urology, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China.
Weichuan ZhangDepartment of Urology, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China.
Chong ShenDepartment of Urology, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China.
Dongli ZhangDepartment of Urology, Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China.
Hebei University of Engineering · CNHandan College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClear cell renal cell carcinoma (ccRCC) is identified as a malignant tumor in the urinary tract. The research was an attempt to probe the biological function and molecular mechanism of lncRNA LINC00667 in ccRCC development.

methodsqRT-PCR monitored LINC00667, miR-143-3p, and ZEB1 levels. The models of LINC00667, miR-143-3p, and ZEB1 overexpression or knockdown were constructed in ccRCC cells. Cell proliferation, apoptosis, migration, and invasion of the cells were detected. The levels of apoptosis-associated proteins and epithelial-mesenchymal transition (EMT)-related proteins, and ZEB1 were detected by WB. Dual-luciferase reporter assay and RNA pull-down assay identified the binding association between LINC00667 and miR-143-3p, miR-143-3p and ZEB1. Moreover, a xenograft tumor model in nude mice was used for evaluating tumor growth

resultsLINC00667 and ZEB1 displayed high expression in ccRCC tissues and cells. miR-143-3p was lowly expressed in ccRCC tissues and cells. LINC00667 targeted and repressed miR-143-3p, which inhibited ZEB1 expression in a targeted manner. Overexpression of LINC00667 facilitated ccRCC cell proliferation, migration, invasion and EMT and retarded apoptosis, whereas LINC00667 knockdown or miR-143-3p overexpression exerted reverse effects. The rescue experiments indicated that overexpressing miR-143-3p dampened LINC00667-mediated oncogenic effects. Overexpressing ZEB1 diminished miR-143-3p-mediated tumor-suppressive effects.

conclusionsLINC00667 is up-regulated in ccRCC and enhances the ZEB1 expression by targeting miR-143-3p, which in turn accelerates ccRCC progression and induces chemoresistance.

Indexed as

CarcinomaCarcinoma, Renal CellKidney NeoplasmsMicroRNAsRNA, Long NoncodingAnimalsCell Line, TumorCell MovementCell ProliferationDrug Resistance, NeoplasmHumansMiceMice, NudeZinc Finger E-box-Binding Homeobox 1MicroRNAsMIRN143 microRNA, humanRNA, Long NoncodingZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1clear cell renal cell carcinomaLINC00667miR-143-3pprogressionZEB1

Identifiers

PMID37827696
PMCPMC10599729
OpenAlexW4387524360

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.