Evidence map›Paper›PMID 37830570›Full record

ArticleCells2023

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia.

Ping Shi, Jia Tian, Julianne C Mallinger, Dahao Ling, Loic P Deleyrolle, Jeremy C McIntyre, Tamara Caspary, Joshua J Breunig, Matthew R Sarkisian

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Ciliary and Non-Ciliary Roles of IFT88 in Development and Diseases.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ping ShiDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0001-9683-8227
Jia TianDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0003-4456-6914
Julianne C MallingerDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Dahao LingDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Loic P DeleyrollePreston A. Wells Jr. Center for Brain Tumor Therapy, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-1129-744X
Jeremy C McIntyreDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Tamara CasparyDepartment of Human Genetics, Emory School of Medicine, Atlanta, GA 30322, USA.
Joshua J BreunigBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Matthew R SarkisianDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA.
University of Florida · USCedars-Sinai Medical Center · USEmory University · US

Funding

Genetic Dissection of Signaling and CiliaR35GM122549 · NIGMS · EMORY UNIVERSITY · PI CASPARY, TAMARA J. · 2017 to 2021
$2.0M
Regulation of the Tumor Immune Cell Landscape by Ciliated Glioblastoma CellsR21NS131636 · NINDS · UNIVERSITY OF FLORIDA · PI SARKISIAN, MATTHEW ROBERT · 2023 to 2024
$419k
NIGMS NIH HHS R35 GM122549NINDS NIH HHS R21 NS131636
6 · The paper itself

Abstract

ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling. Gliomas with increased

Indexed as

CiliaGliomaADP-Ribosylation FactorsHedgehog ProteinsHumansPhosphoinositide 5-PhosphatasesPhosphoric Monoester HydrolasesSmoothened ReceptorZinc Finger Protein Gli2ADP-Ribosylation FactorsARL13B protein, humanHedgehog ProteinsPhosphoinositide 5-PhosphatasesPhosphoric Monoester HydrolasesSmoothened ReceptorZinc Finger Protein Gli2cyclopamineGLI2glioblastomahedgehogIFT88INPP5eprimary ciliasmoothenedvismodegib

Identifiers

PMID37830570
PMCPMC10571910
OpenAlexW4387049321

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.