Evidence map›Paper›PMID 37830576›Full record

ArticleCells2023

Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2.

Per Kristian Lunde, Ornella Manfra, Thea Parsberg Støle, Marianne Lunde, Marita Martinsen, Cathrine Rein Carlson, William E Louch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Per Kristian LundeInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Ornella ManfraInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Thea Parsberg StøleInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.ORCID 0009-0006-9729-2127
Marianne LundeInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Marita MartinsenInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Cathrine Rein CarlsonInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
William E LouchInstitute for Experimental Medical Research, Oslo University Hospital and University of Oslo, 0450 Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-penetrating peptides (CPPs) are short peptide sequences that have the ability to cross the cell membrane and deliver cargo. Although it is critical that CPPs accomplish this task with minimal off-target effects, such actions have in many cases not been robustly screened. We presently investigated whether the commonly used CPPs TAT and the polyarginines Arg

Indexed as

Cell-Penetrating PeptidesSarcoplasmic Reticulum Calcium-Transporting ATPasesMuscle, SkeletalPeptidesProtein IsoformsCell-Penetrating PeptidesPeptidespolyarginineProtein IsoformsSarcoplasmic Reticulum Calcium-Transporting ATPasescalcium homeostasiscell-permeating peptidesSERCA2

Identifiers

PMID37830576
PMCPMC10571751
OpenAlexW4387050305

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.