Evidence map›Paper›PMID 37830599›Full record

ArticleCells2023

The Effects of Aging on Rod Bipolar Cell Ribbon Synapses.

Abhishek P Shrestha, Nirujan Rameshkumar, Johane M Boff, Rhea Rajmanna, Thadshayini Chandrasegaran, Courtney E Frederick, David Zenisek, Thirumalini Vaithianathan

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Abhishek P ShresthaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Nirujan RameshkumarDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Johane M BoffDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0009-9952-0674
Rhea RajmannaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Thadshayini ChandrasegaranDepartment of Zoology, Faculty of Science, University of Jaffna, Jaffna 40000, Sri Lanka.
Courtney E FrederickDepartment of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA.
David ZenisekDepartment of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Thirumalini VaithianathanDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7686-5284
University of Tennessee Health Science Center · USYale University · USUniversity of Jaffna · LK

Funding

Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI Jonathan B Demb · 2016 to 2026
$7.1M
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses.R01EY030863 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI VAITHIANATHAN, THIRUMALINI · 2021 to 2025
$2.3M
Synaptic transmission at retinal ribbon synapsesR01EY032396 · NEI · YALE UNIVERSITY · PI THORESON, WALLACE B, ZENISEK, DAVID PAUL · 2021 to 2024
$1.9M
NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY030863NEI NIH HHS R01 EY032396
6 · The paper itself

Abstract

The global health concern posed by age-related visual impairment highlights the need for further research focused on the visual changes that occur during the process of aging. To date, multiple sensory alterations related to aging have been identified, including morphological and functional changes in inner hair cochlear cells, photoreceptors, and retinal ganglion cells. While some age-related morphological changes are known to occur in rod bipolar cells in the retina, their effects on these cells and on their connection to other cells via ribbon synapses remain elusive. To investigate the effects of aging on rod bipolar cells and their ribbon synapses, we compared synaptic calcium currents, calcium dynamics, and exocytosis in zebrafish (

Indexed as

CalciumZebrafishAgingAnimalsRetinaSynapsesCalciumagingcalcium dynamicsconfocal imagingelectrophysiologypatch clampingretinaribbon synapsesvision

Identifiers

PMID37830599
PMCPMC10572008
OpenAlexW4387234631

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.