Evidence map›Paper›PMID 37830620›Full record

ArticleCells2023

PolyQ-Expansion Causes Mitochondria Fragmentation Independent of Huntingtin and Is Distinct from Traumatic Brain Injury (TBI)/Mechanical Stress-Mediated Fragmentation Which Results from Cell Death.

Kelsey Swinter, Dania Salah, Rasika Rathnayake, Shermali Gunawardena

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelsey SwinterDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Dania SalahDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Rasika RathnayakeDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Shermali GunawardenaDepartment of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.ORCID 0000-0001-8776-9397
University at Buffalo, State University of New York · US

Funding

Dissecting the in vivo role of glycogen synthase kinase-3 beta (GSK3b) in the function of kinesin-1 using CRISPR/cas-1R03NS114731 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GUNAWARDENA, SHERMALI · 2020 to 2020
$157k
Dissecting the in vivo role of Huntingtin in Rab vesicle movement on microtubulesR03NS084386 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GUNAWARDENA, SHERMALI · 2013 to 2014
$155k
NINDS NIH HHS R03 NS084386NINDS NIH HHS R03 NS114731
6 · The paper itself

Abstract

Mitochondrial dysfunction has been reported in many Huntington's disease (HD) models; however, it is unclear how these defects occur. Here, we test the hypothesis that excess pathogenic huntingtin (HTT) impairs mitochondrial homeostasis, using

Indexed as

Brain Injuries, TraumaticHuntington DiseaseAnimalsCell DeathDrosophilaMitochondriaPeptidesStress, MechanicalPeptidespolyglutamineDrosophilaexpansion of polyQ repeatshuntingtinmechanical stress/traumatic brain injurymitochondria

Identifiers

PMID37830620
PMCPMC10572422
OpenAlexW4387377912

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.