Evidence map›Paper›PMID 37832274›Full record

ArticleJournal of psychosomatic research2023

Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study.

Yufen Lin, Gang Peng, Deborah W Bruner, Andrew H Miller, Nabil F Saba, Kristin A Higgins, Dong M Shin, Henry Claussen, H Richard Johnston, Madelyn C Houser and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosomatic research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yufen LinNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, USA; Winship Cancer Institute, Emory University, Atlanta, USA.
Gang PengDepartment of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, USA.
Deborah W BrunerNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, USA; Winship Cancer Institute, Emory University, Atlanta, USA; School of Medicine, Emory University, Atlanta, USA.
Andrew H MillerWinship Cancer Institute, Emory University, Atlanta, USA; School of Medicine, Emory University, Atlanta, USA.
Nabil F SabaWinship Cancer Institute, Emory University, Atlanta, USA; School of Medicine, Emory University, Atlanta, USA.
Kristin A HigginsWinship Cancer Institute, Emory University, Atlanta, USA; School of Medicine, Emory University, Atlanta, USA.
Dong M ShinWinship Cancer Institute, Emory University, Atlanta, USA; School of Medicine, Emory University, Atlanta, USA.
Henry ClaussenEmory Integrated Computational Core, Emory University, Atlanta, USA.
H Richard JohnstonEmory Integrated Computational Core, Emory University, Atlanta, USA.
Madelyn C HouserNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, USA.
Evanthia C WommackSchool of Medicine, Emory University, Atlanta, USA.
Canhua XiaoNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, USA; Winship Cancer Institute, Emory University, Atlanta, USA. Electronic address: canhua.xiao@emory.edu.
Emory University · USIndiana University – Purdue University Indianapolis · US

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5M
Epigenetic Mechanisms of Inflammation and Fatigue in Head and Neck Cancer PatientsR01NR015783 · NINR · EMORY UNIVERSITY · PI XIAO, CANHUA · 2016 to 2018
$1.5M
Fatigue in Head and Neck Cancer: Role of pro- and anti-inflammatory signalingR00NR014587 · NINR · EMORY UNIVERSITY · PI XIAO, CANHUA · 2015 to 2017
$706k
NCI NIH HHS P30 CA138292NINR NIH HHS R00 NR014587NINR NIH HHS R01 NR015783
6 · The paper itself

Abstract

objectivePatients with head and neck cancer (HNC) experience psychoneurological symptoms (PNS, i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity-modulated radiotherapy (IMRT) that negatively impact their functional status, quality of life, and overall survival. The underlying mechanisms for PNS are still not fully understood. This study aimed to examine differentially expressed genes and pathways related to PNS for patients undergoing IMRT (i.e., before, end of, 6 months, and 12 months after IMRT).

methodsParticipants included 142 patients with HNC (mean age 58.9 ± 10.3 years, 72.5% male, 83.1% White). Total RNA extracted from blood leukocytes were used for genome-wide gene expression assays. Linear mixed effects model was used to examine the association between PNS and gene expression across time. Gene Ontology (GO) enrichment analysis was employed to identify pathways related to PNS.

resultsA total of 1352 genes (162 upregulated, 1190 downregulated) were significantly associated with PNS across time (false discovery rate (FDR) < 0.05). Among these genes, 112 GO terms were identified (FDR < 0.05). The top 20 GO terms among the significant upregulated genes were related to immune and inflammatory responses, while the top 20 GO terms among the significant downregulated genes were associated with telomere maintenance.

conclusionThis study is the first to identify genes and pathways linked to immune and inflammatory responses and telomere maintenance that are associated with PNS in patients with HNC receiving IMRT. Inflammation and aging markers may be candidate biomarkers for PNS. Understanding biological markers may produce targets for novel interventions.

Indexed as

Head and Neck NeoplasmsRadiotherapy, Intensity-ModulatedAgedFemaleHumansInflammationLongitudinal StudiesMaleMiddle AgedQuality of LifeGene expressionHead and neck cancerPathwaysRadiotherapySymptoms

Identifiers

PMID37832274
PMCPMC11789059
OpenAlexW4387498243

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.