Evidence map›Paper›PMID 37832467›Full record

ArticleJournal of colloid and interface science2024

Enhanced antibacterial efficacy against antibiotic-resistant bacteria via nitric oxide-releasing ampicillin polymer substrates.

Yi Wu, Mark R Garren, Lori M Estes Bright, Patrick Maffe, Megan Brooks, Elizabeth J Brisbois, Hitesh Handa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yi WuSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Mark R GarrenSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Lori M Estes BrightSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Patrick MaffeSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Megan BrooksSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Elizabeth J BrisboisSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States. Electronic address: ejbrisbois@uga.edu.
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States; Pharmaceutical and Biomedical Science Department, College of Pharmacy, University of Georgia, Athens, GA 30602, United States. Electronic address: hhanda@uga.edu.
University of Georgia · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Bioinspired antifouling and thromboresistant polymers for blood-contacting interfacesR01HL151473 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2020 to 2023
$1.4M
NCATS NIH HHS UL1 TR002378NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL151473
6 · The paper itself

Abstract

The emergence of antibiotic-resistant bacteria poses a pressing threat to global health and is a leading cause of healthcare-related morbidity and mortality. Herein, we report the fabrication of medical-grade polymers incorporated with a dual-action S-nitroso-N-acetylpenicillamine-functionalized ampicillin (SNAPicillin) conjugated molecule through a solvent evaporation process. The resulting SNAPicillin-incorporated polymer materials act as broad-spectrum antibacterial surfaces that improve the administration efficacy of conventional antibiotics through the targeted release of both nitric oxide and ampicillin. The polymer surfaces were characterized by scanning electron microscopy and static contact angle measurements. The nitric oxide (NO) release profile and diffusion of SNAPicillin from polymers were quantified using a chemiluminescence-based nitric oxide analyzer (NOA) and ultraviolet-visible (UV-vis) spectroscopy. As a result, the films had up to 2.96 × 10

Indexed as

Anti-Bacterial AgentsNitric OxideAmpicillinAnimalsMicePolymersS-Nitroso-N-AcetylpenicillamineStaphylococcus aureusAmpicillinAnti-Bacterial AgentsNitric OxidePolymersS-Nitroso-N-AcetylpenicillamineAmpicillinAntibacterial surfaceAntibioticsNitric oxideS-nitroso-N-acetylpenicillamine

Identifiers

PMID37832467
PMCPMC10593200
OpenAlexW4387233188

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.