Evidence map›Paper›PMID 37833621›Full record

ArticleBMC cancer2023

Circular RNA CCT3 is a unique molecular marker in bladder cancer.

Lin Luo, Qingzhi Xie, Yunchou Wu, Ping Li, FuQiang Qin, Dunming Liao, KangNing Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lin Luo *Department of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China.
Qingzhi Xie *Department of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China.
Yunchou WuDepartment of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China.
Ping LiDepartment of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China.
FuQiang QinDepartment of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China.
Dunming LiaoDepartment of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China.
KangNing WangDepartment of urology surgery, The First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang City, Hunan Province, 422000, China. 208102105@csu.edu.cn.
Shaoyang University · CNXiangya Hospital Central South University · CN

Funding

Scientific Research Project of Hunan Provincial Department of Education 18C0825
6 · The paper itself

Abstract

This study surveyed circular RNA CCT3 in bladder cancer (BCa). We recruited 85 BCa patients and 40 normal controls (Normal) and collected clinical specimens for analysis. circRNA CCT3 expression was analyzed by RT-qPCR, diagnostic accuracy was calculated by ROC curves, and survival outcomes were evaluated by survival curves. CircRNA CCT3 was overexpressed or knocked down in cells, thereafter to observe the changes in cell malignant phenotypes. The downstream molecules of circRNA CCT3 were detected. Our data suggest that circRNA CCT3 was upregulated in human BCa and was associated with poor survival outcomes of BCa patients. In cell experiments, overexpressing circRNA CCT3 promoted BCa cell malignancy, whereas silencing circRNA CCT3 did the opposite. In addition, circRNA CCT3 modulated PP2A expression by miR-135a-5p. This study demonstrates that circRNA CCT3 is a diagnostic and prognostic biomarker in BCa patients and is a tumor promoter in BCa.

Indexed as

MicroRNAsUrinary Bladder NeoplasmsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationChaperonin Containing TCP-1Gene Expression Regulation, NeoplasticHumansRNA, CircularBiomarkers, TumorCCT3 protein, humanChaperonin Containing TCP-1MicroRNAsRNA, CircularBladder cancerCircular RNA CCT3DiagnosismiR-135a-5pMolecular markerPP2APrognosis

Identifiers

PMID37833621
PMCPMC10571266
OpenAlexW4387610065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.