Evidence map›Paper›PMID 37833739›Full record

ArticleJournal of translational medicine2023

Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents.

Benedetta Perrone, Paola Ruffo, Giuseppina Augimeri, Diego Sisci, Maria Stefania Sinicropi, Giovanni Tripepi, Corrado Mammì, Daniela Bonofiglio, Francesca Luisa Conforti

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Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benedetta PerroneDepartment of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Paola RuffoDepartment of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Giuseppina AugimeriDepartment of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Diego SisciDepartment of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Maria Stefania SinicropiDepartment of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Giovanni TripepiInstitute of Clinical Physiology of Reggio Calabria, IFC-CNR, Reggio Calabria, Italy.
Corrado Mammì *Great Metropolitan Hospital BMM, Reggio Calabria, Italy. corradomammi@tiscali.it.
Daniela Bonofiglio *Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Francesca Luisa Conforti *Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy. francescaluisa.conforti@unical.it.ORCID http://orcid.org/0000-0001-8364-1783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe complex interplay between health, lifestyle and genetics represents a critical area of research for understanding and promoting human well-being. Importantly, genetics plays a key role in determining individual susceptibility to disease and response to lifestyle. The aim of the present study was to identify genetic factors related to the metabolic/inflammatory profile of adolescents providing new insights into the individual predisposition to the different effects of the substances from the environment.

methodsAssociation analysis of genetic variants and biochemical parameters was performed in a total of 77 healthy adolescents recruited in the context of the DIMENU study.

resultsPolymorphisms of 3-hydroxy-3-methylglutaril coenzyme A reductase (HMGCR; rs142563098), C-reactive protein gene (CRP; rs1417938, rs1130864), cholesteryl ester transfer protein (CETP; rs5030708), interleukin (IL)-10 (IL-10; rs3024509) genes were significantly associated (p < 0.05) with various serum metabolic parameters. Of particular interest were also the correlations between the HMGCRpolymorphism (rs3846663) and tumor necrosis factor (TNF)-α levels, as well Fatty-acid desaturase (FADS) polymorphism (rs7481842) and IL-10 level opening a new link between lipidic metabolism genes and inflammation.

conclusionIn this study, we highlighted associations between single nucleotide polymorphisms (SNPs) and serum levels of metabolic and inflammatory parameters in healthy young individuals, suggesting the importance of genetic profiling in the prevention and management of chronic disease.

Indexed as

Interleukin-10Polymorphism, Single NucleotideAdolescentAllelesCholesterol Ester Transfer ProteinsGenetic Predisposition to DiseaseGenotypeHumansHydroxymethylglutaryl CoA ReductasesInflammationReceptors, ImmunologicTumor Necrosis Factor-alphaCETP protein, humanCholesterol Ester Transfer ProteinsCRP protein, humanHMGCR protein, humanHydroxymethylglutaryl CoA ReductasesInterleukin-10Receptors, ImmunologicTumor Necrosis Factor-alphaHealthInflammationLipid profileMetabolic parametersSNPStatin

Identifiers

PMID37833739
PMCPMC10576320

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