Evidence map›Paper›PMID 37833870›Full record

ArticleInternational journal of molecular sciences2023

Disrupting the Repeat Domain of Premelanosome Protein (PMEL) Produces Dysamyloidosis and Dystrophic Ocular Pigment Reflective of Pigmentary Glaucoma.

Elizabeth D Hodges, Paul W Chrystal, Tim Footz, Lance P Doucette, Nicole C L Noel, Zixuan Li, Michael A Walter, W Ted Allison

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pmel17 Deficiency Affects Melanogenesis and Promotes Tumor Vascularization.International journal of molecular sciences · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Elizabeth D HodgesDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Paul W ChrystalDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.ORCID 0000-0002-5371-1178
Tim FootzDepartment of Medical Genetics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Lance P DoucetteDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Nicole C L NoelDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.ORCID 0000-0001-9094-6745
Zixuan LiDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Michael A WalterDepartment of Medical Genetics, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0002-0567-0113
W Ted AllisonDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.ORCID 0000-0002-8461-4864
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pigmentary glaucoma has recently been associated with missense mutations in

Indexed as

Glaucoma, Open-AngleNeurodegenerative DiseasesAmyloidAnimalsEyegp100 Melanoma AntigenHumansMelanosomesYoung AdultZebrafishAmyloidgp100 Melanoma AntigenPMEL protein, humanmelaninmelanosomepigment dispersion syndromePMEL17prion-likeretinaSILV

Identifiers

PMID37833870
PMCPMC10572516
OpenAlexW4386963788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.