Evidence map›Paper›PMID 37834023›Full record

ArticleInternational journal of molecular sciences2023

Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.

Michelle Rodriguez Garcia, Jeffrey Schmeckpeper, Maicon Landim-Vieira, Isabella Leite Coscarella, Xuan Fang, Weikang Ma, Payton A Spran, Shengyao Yuan, Lin Qi, Aida Rahimi Kahmini and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Michelle Rodriguez GarciaBiomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.
Jeffrey SchmeckpeperDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0001-9437-5871
Maicon Landim-VieiraBiomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-6696-8888
Isabella Leite CoscarellaBiomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-9706-9319
Xuan FangDepartment of Cell & Molecular Physiology, Loyola University, Chicago, IL 60660, USA.ORCID 0000-0001-6394-4015
Weikang MaBioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.ORCID 0000-0001-9535-7114
Payton A SpranDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Shengyao YuanBioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Lin QiBioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Aida Rahimi KahminiDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-6319-9614
M Benjamin ShoemakerDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
James B AtkinsonDepartment of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Peter M Kekenes-HuskeyDepartment of Cell & Molecular Physiology, Loyola University, Chicago, IL 60660, USA.
Thomas C IrvingBioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.ORCID 0000-0003-4848-3323
Prescott Bryant ChaseDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-9701-561X
Björn C KnollmannDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jose Renato PintoBiomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0001-9092-4976
Florida State University · USIllinois Institute of Technology · USVanderbilt University Medical Center · USLoyola University Chicago · US

Funding

The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
The mechanisms of cardiac thin filament regulation in health and disease.R01HL160966 · NHLBI · OLD DOMINION UNIVERSITY · PI CHASE, P. BRYANT, GALKIN, VITOLD · 2022 to 2025
$2.3M
Modulators of Cardiomyopathic DiseasesR01HL128683 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2016 to 2020
$1.8M
Probing macrophage cell nucleotide sensing and calcium signaling through computationR35GM148284 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI Peter Michael Kekenes-Huskey · 2023 to 2026
$1.5M
NHLBI NIH HHS R01 HL128683NHLBI NIH HHS R01 HL160966NHLBI NIH HHS R35 HL144980NIGMS NIH HHS P30 GM138395NIGMS NIH HHS R35 GM148284
6 · The paper itself

Abstract

The

Indexed as

ActininMyofibrilsConnectinHumansMyocardiumMyocytes, CardiacSarcomeresActininACTN2 protein, humanConnectinACTN2cardiomyopathymuscle mechanicsZ-discα-actinin 2

Identifiers

PMID37834023
PMCPMC10572656
OpenAlexW4387059948

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.