Evidence map›Paper›PMID 37834059›Full record

ReviewInternational journal of molecular sciences2023

Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy.

Samantha Schimmel, Bassel El Sayed, Gavin Lockard, Jonah Gordon, Isabella Young, Francesco D'Egidio, Jea Young Lee, Thomas Rodriguez, Cesar V Borlongan

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06816199 (A Prospective Cohort Study Exploring the Safety and the Efficiency of Hyperbaric Oxygen in Treating Traumatic Brain Injury During Nonacute Phrase), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06816199 recruitingnot on this mapstarted 2025, after this paper: background citation

A Prospective Cohort Study Exploring the Safety and the Efficiency of Hyperbaric Oxygen in Treating Traumatic Brain Injury During Nonacute Phrase

Typeobservational_patient_registrySponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2025 to 2030Enrolled300ConditionsTraumatic Brain InjuryArmsHyperbaric oxygen exposure
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samantha SchimmelMorsani College of Medicine, University of South Florida, 560 Channelside Dr., Tampa, FL 33602, USA.
Bassel El SayedMorsani College of Medicine, University of South Florida, 560 Channelside Dr., Tampa, FL 33602, USA.
Gavin LockardMorsani College of Medicine, University of South Florida, 560 Channelside Dr., Tampa, FL 33602, USA.ORCID 0000-0001-5016-209X
Jonah GordonMorsani College of Medicine, University of South Florida, 560 Channelside Dr., Tampa, FL 33602, USA.ORCID 0000-0002-9161-5160
Isabella YoungUniversity of Arkansas, Fayetteville, AR 72701, USA.ORCID 0009-0002-6184-9051
Francesco D'EgidioCenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.ORCID 0000-0001-9695-6274
Jea Young LeeCenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.ORCID 0000-0001-5270-3224
Thomas RodriguezSchool of Medicine, Loma Linda University, 11175 Campus St., Loma Linda, CA 92350, USA.
Cesar V BorlonganCenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA.ORCID 0000-0002-2966-9782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment.

Indexed as

Brain InjuriesBrain Injuries, TraumaticHyperbaric OxygenationBrainHumansOxygenOxygenchronic impairmentshyperbaric oxygen therapytraumatic brain injury

Identifiers

PMID37834059
PMCPMC10572450

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.