Evidence map›Paper›PMID 37834104›Full record

ArticleInternational journal of molecular sciences2023

Design, Synthesis, and Potent Anticancer Activity of Novel Indole-Based Bcl-2 Inhibitors.

Ahmed M Almehdi, Sameh S M Soliman, Abdel-Nasser A El-Shorbagi, Andrew D Westwell, Rania Hamdy

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Ahmed M AlmehdiCollege of Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Sameh S M SolimanResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.ORCID 0000-0002-7691-615X
Abdel-Nasser A El-ShorbagiCollege of Pharmacy, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Andrew D WestwellSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, Cardiff CF10 3NB, UK.ORCID 0000-0002-5166-9236
Rania HamdyResearch Institute for Science and Engineering (RISE), University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
University of Sharjah · AECardiff University · GBZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Bcl-2 family plays a crucial role in regulating cell apoptosis, making it an attractive target for cancer therapy. In this study, a series of indole-based compounds,

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansIndolesMolecular Docking SimulationMolecular StructureProto-Oncogene Proteins c-bcl-2Structure-Activity RelationshipAntineoplastic AgentsIndolesProto-Oncogene Proteins c-bcl-2anti-apoptotic proteinBcl-2cancer drug discoveryindole

Identifiers

PMID37834104
PMCPMC10572575
OpenAlexW4387137836

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.