ArticleInternational journal of molecular sciences2023
High-Carbohydrate Diet Consumption Poses a More Severe Liver Cholesterol Deposition than a High-Fat and High-Calorie Diet in Mice.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Comparison of Physiological Responses to Plant-Protein- and Carbohydrate-Based Fishmeal Substitutes in Largemouth Bass (Animals : an open access journal from MDPI · 2026Article
- An Evaluation of the Effects of the Ruthenium (II)-Uracil Schiff Base Complex on Selected Markers of Glucose Homeostasis in Diet-Induced Prediabetic Male Rats.Pharmaceutics · 2026Article
- Development of a standardized murine model for investigating cholesterol crystallization and deposition in the gallbladder wall: effects of dietary cholesterol and pharmacological modulation.European journal of medical research · 2026Article
- Diallyl trisulfide attenuates metabolic syndromeFrontiers in pharmacology · 2026Article
- A moderate lard-included diet reduces fat deposition and inflammation in the adipose tissue.NPJ science of food · 2025Article
- Nutritional and Fasting Strategies for the Management of MASLD/MASH: An Integrative Review.JGH open : an open access journal of gastroenterology and hepatology · 2025Review
- T-2 Toxin Exploits Gut-Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Static magnetic field exposure modulates gut microbiota and host metabolism to alleviate high-fat diet-induced metabolic dysfunction-associated fatty liver disease.Zoological research · 2025Article
- Article
- The global landscape of lean metabolic dysfunction-associated steatotic liver disease: insight from Asia and the West.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Review
- Effect of areca nut extracts on growth performance, slaughtering performance, and meat quality of broiler chickens.Frontiers in veterinary science · 2025Article
- Assessment of lipid profile and its association with acne vulgaris severity in adolescents and young adults: A cross-sectional study in Kurdistan Region, Iraq.Qatar medical journal · 2025Article
- The Sex Dependent and Independent Effects of Dietary Whey Proteins Are Passed from the Mother to the Offspring.Molecular nutrition & food research · 2024Article
- Article
- Both Maternal High-Fat and Post-Weaning High-Carbohydrate Diets Increase Rates of Spontaneous Hepatocellular Carcinoma in Aged-Mouse Offspring.Nutrients · 2024Article
- Article
- Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver.Metabolites · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
In the past few decades, many researchers believed that a high-fat and high-calorie diet is the most critical factor leading to metabolic diseases. However, increasing evidence shows a high-carbohydrate and low-fat diet may also be a significant risk factor. It needs a comprehensive evaluation to prove which viewpoint is more persuasive. We systematically compared the effects of high-fat and high-calorie diets and high-carbohydrate and low-fat ones on glycolipid metabolism in mice to evaluate and compare the effects of different dietary patterns on metabolic changes in mice. Sixty 8-week-old male C57BL/6 mice were divided into four groups after acclimatization and 15% (F-15), 25% (F-25), 35% (F-35), and 45% (F-45) of their dietary energy was derived from fat for 24 weeks. The body weight, body-fat percentage, fasting blood glucose, lipid content in the serum, and triglyceride content in the livers of mice showed a significantly positive correlation with dietary oil supplementation. Interestingly, the total cholesterol content in the livers of mice in the F-15 group was significantly higher than that in other groups (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.