Evidence map›Paper›PMID 37834349›Full record

ArticleInternational journal of molecular sciences2023

Crystal Structure of DNA Replication Protein SsbA Complexed with the Anticancer Drug 5-Fluorouracil.

Hsin-Hui Su, Yen-Hua Huang, Yi Lien, Po-Chun Yang, Cheng-Yang Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Hsin-Hui SuDepartment of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 717, Taiwan.
Yen-Hua HuangDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.ORCID 0000-0001-6347-3030
Yi LienDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-1613-552X
Po-Chun YangDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.ORCID 0000-0003-0987-7434
Cheng-Yang HuangDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan.
Chung Shan Medical University · TWChia Nan University of Pharmacy and Science · TWChung Shan Medical University Hospital · TWPurdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-stranded DNA-binding proteins (SSBs) play a crucial role in DNA metabolism by binding and stabilizing single-stranded DNA (ssDNA) intermediates. Through their multifaceted roles in DNA replication, recombination, repair, replication restart, and other cellular processes, SSB emerges as a central player in maintaining genomic integrity. These attributes collectively position SSBs as essential guardians of genomic integrity, establishing interactions with an array of distinct proteins. Unlike

Indexed as

Antineoplastic AgentsBacterial ProteinsDNA ReplicationDNA, Single-StrandedEscherichia coliFluorouracilGlycerolHumansProtein BindingAntineoplastic AgentsBacterial ProteinsDNA, Single-StrandedFluorouracilGlycerol5-fluorouracilanticancer drugconformational changecrystal structuredockingsingle-stranded DNA-binding proteinSSBSsbA

Identifiers

PMID37834349
PMCPMC10573954
OpenAlexW4387344137

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.